234 Dr. A. Breinl. On the Histology of [Apr. 8, 



neurium of the peripheral nerves were seen. In two cases of longer duration 

 and with more pronounced symptoms of the disease, more definite changes 

 around the vessels of the brain and spinal cord were seen than in the third 

 case of shorter duration with less marked symptoms. In this case the peri- 

 vascular changes in the brain were small and were still less so in the spinal 

 cord. 



In all groups of the lymph glands numerous ones were found showing the 

 typical appearance of hsemo-lymph glands with a pronounced hyperplasia of 

 the connective tissue, a widening of the follicles and the formation of a 

 system of sinuses containing red blood cells and large phagocytes in a fine 

 threadwork of connective tissue. Others showed a transition between the 

 lucmo-lymph glands and normal glands, one part appearing normal, the other 

 presenting a typical sinus formation with numerous red blood cells and 

 phagocytes. Nearly all the glands contained between the lymph cells a 

 number of blood corpuscles, many in all stages of degeneration. The spleen 

 was greatly congested and contained a few necrotic areas, scattered through 

 the organ was a little blood pigment giving the iron reaction. The bone 

 marrow exhibited the typical picture of red marrow with gelatinous 

 degeneration. The liver and kidneys showed haemorrhages between the 

 parenchyma cells, which latter appeared to be undergoing degeneration. In 

 all three cases a few large bacilli and cocci were seen which did not stain 

 by Gram's method, these I consider to be due to post-mortem contamination. 



The bacteriological cultivation, anaerobic and aerobic of the cerebro-spinal 

 fluid and the blood of two cases, did not give any growth, and moreover, 

 animals infected with large quantities of cerebro-spinal fluid or blood did not 

 show any other symptoms than those caused through the presence of 

 trypanosomes in the blood. 



In only one case, dying with a fair number of trypanosomes in the blood, 

 could I find occasionally a parasite in the congested vessels of the organs. 



The one case of trypanosomiasis, which died from an intercurrent 

 pneumonia, did not show any other changes in the central nervous system 

 than the very large peri-vascular spaces, partially filled with transudate, 

 and sometimes containing a few white blood corpuscles. The ganglion 

 cells showed the changes corresponding to the hyperthermia. The lymph 

 glands were very hemorrhagic, some showed the typical appearance of hremo- 

 lymph glands. 



The brains, spinal cords, and organs of numerous animals infected with 

 Trypanosoma Gambiense, monkeys, rabbits, guinea-pigs, dogs, rats, and mice 

 were examined. One of the monkeys showed a typical hemorrhagic cicatrix 

 in the left lobus centralis of the brain ; other monkeys and a chimpanzee 



