298 Mr. E. E. Henderson and Prof. E. H. Starling. [Nov. 23, 



aorta a large rise of blood pressure was produced in this eye, since all the 

 blood had to pass through the one carotid artery in order to get back to the 

 heart. On the other hand, an almost complete anaemia could be produced in 

 the eye by obstruction of the one remaining carotid. We give below the 

 results of one such experiment. 



Cat, anaesthetised with Ether and the A.C.E. Mixture. A small dose of 

 Curare was injected after anaesthesia was complete. The extract of 

 2 grammes of dried leech heads was injected. 



Time. 



B.P. in mm. 

 Hg. 



Weight of 

 secretion. 



Weight of 

 solids after 

 drying to a 

 constant 

 weight. 



Percentage 

 of solids. 



Rate of flow 

 per minute. 







grammes. 



grammes. 





grammes. 



3.50 cannula inserted. 













3.51 



130 



0-689 



009 



1 -3 





3.56 



145 



0-252 



0-007 



2-7 



05 



4.16 



120 



0-756 



032 



4-2 



037 



4.36 



100 



0-475 



0-021 



4-4 



023 



4.56 



96 



0-482 



0-024 



4-9 



0-024 



Dog. Weight, 7^ kilos. Anaesthetised with the A.C.E. mixture and morphia- 

 The extract of 2 grammes of dried leech heads was injected. Both 

 subclavians and vertebrals were tied. Temporary ligature round aorta. 

 Cannula in left eye. B.P. observed in right carotid. 



Time. 



B.P. in 

 mm. Hg. 



Amount of 

 secretion in 

 grammes. 



Total 

 solids in 

 grammes. 



Percentage 

 of solids. 



Rate of 

 flow. 



Eemarks. 



3-29 













Cannula inserted. Aorta 















unobstructed 



3-30 



110 



0-811 



013 



1-5 







3 35 



110 



0-432 



014 



3 2 



0-086 





3 -45 



100 



0-550 



0-027 



4-9 



0-055 





3-55 



205 



1 153 



0-068 



5-9 



0-115 



Aorta obstructed. Fluid 















tinged red. 



4-5 



100 



0-627 



0-039 



6-2 



0-062 



Aorta unobstructed. 



4-15 



198 



-816 



053 



6-6 



0-081 



Aorta obstructed. 



It will be seen that in every case a rise of intraocular pressure caused an 

 increase in the amount of fluid secreted. It is impossible, however, to deduce 

 directly from these experiments that the intraocular fluid is a transudation. 

 The opening of the eye-ball and the consequent diminution of the intraocular 

 pressure to nothing have a serious effect on all the intraocular structures. 



