1905.] 



On the Production of Intraocular Fluid. 



307 



After the determination of the intraocular pressure, the animal was killed 

 by opening its heart, and the inflow of serum and saline fluid respectively 

 observed, first under the normal intraocular pressure, and then under raised 

 pressures. 



The results of two such experiments are given below. It will be seen that 

 there is a marked difference in the rate of filtration of the two fluids, that of 

 serum being, as one might predict, very much slower than that of saline.* 



Experiment 1. — Dog, A.C.E. Morphia. Curare. Vagi cut. 



Time. 



Blood pressure. 



Intraocular pressure. 



Salt eye. 



Serum eye. 



4.15 

 4.20 

 4.45 

 Animal killed 



70 mm. Hg. 

 70 

 100 



by opening hear 



26 "2 

 24-2 

 29 -2 



t. 



29 - 4 cm. water. 



27 



29 





Inflow per minute in cubic milli- 



Pressure. 



metres (after 10 minutes). 







1 



Salt. Serum. 



29 cm. 



11 -5 6 





11-5 6 





11-5 6 



Experiment 2. — Cat. Ether, morphia, curare. 



Time. 



Blood pressure. 



Intraocular pressure. 



Salt. 



Serum. 



3.0 p.m. 

 3.10 

 3.20 

 Animal kille 



120 

 116 

 110 



d. 



14 -8 

 10 8 

 9 2 



15 1 

 12 5 

 11-5 



* Although serum filters more slowly than normal intraocular fluid ox' saline, the 

 difference is not sufficiently great to cause any marked variation in the intraocular 

 pressures on the two sides. One cannot, therefore, in view of these observations, ascribe 

 any large part in the production of any form of glaucoma to possible differences in 

 the composition of the aqueous humour which might be determined by inflammatory 

 conditions of the blood vessels. 



VOL. LXXVII. — B. Z 



