440 



Dr. C. Bolton. On the 



[Jan. 25, 



Note. — The term " Hemolytic lesions " is used in this paper to signify the 

 haemorrhages which are produced by the injection of a haemolytic serum ; this 

 does not however imply that such haemorrhages are directly caused by the 

 factor in the serum which brings about solution of the red blood corpuscles. 



KEFERENCES. 



1. Gay, "Observations on the Single Nature of Hemolytic Immune Bodies, and on the 



Existence of so-called ' Complementoids,' " ' Centralbl. f. Bakt., etc.,' 1 Abt., 

 Originale, vol. 39, heft 2, 1905, p. 172. 



2. Bashford, 'Journal of Hygiene,' vol. 4, 1904, No. 1, p. 40. 



3. Ehrlich and Morgenroth, 'Berl. Kdin. Wehschr.,' 1901, p. 569—598, and 1900, p. 681. 



4. Muir and Browning, ' Roy. Soc. Proc.,' vol. 74, 1904, p. 298. 



5. Gay, loc. cit. 



DESCRIPTION OF PLATES. 

 Plate 16. 



Fig. 1. — Illustrates the removal of the gastrotoxin from the serum by treatment with 



guinea-pig's stomach cells previous to its injection. 

 Upper Stomach. — From a guinea-pig injected with gastrotoxic serum. Necrosis 



of the mucous membrane has therefore resulted. 

 Lower Stomach. — From a guinea-pig injected with the same dose of the same 



serum previously treated with stomach cells. No lesion has resulted ; the 



stomach cells have removed the gastrotoxin from the serum by combining 



with it. 



Fig. 2. — Stomach of a guinea-pig which was injected with gastrotoxic serum previously 

 treated with guinea-pig's small intestine cells. The gastrotoxin has not been 

 removed from the serum by the cells, and the stomach therefore shows 

 necrosis of the mucous membrane. 



Fig. 3.— Stomach of a guinea-pig which was injected with gastrotoxic serum previously 

 treated with guinea-pig's liver cells. The gastrotoxin has not been removed 

 from the serum by the liver cells, and the stomach therefore shows a patch 

 of necrosis of the mucous membrane. The action of the serum has, however, 

 been weakened. 



Fig. 4. — The lower stomach is that of a guinea-pig which was injected with gastrotoxic 

 serum previously treated with guinea-pig's liver cells. The gastrotoxin has 

 been removed in this case by the liver cells, and the stomach therefore 

 shows no lesion. 



The upper stomach is from the control animal, which was injected with untreated 

 serum, and shows lesions which are relatively slight. 



Plate 17. 



Fig. 5. — Illustrates the fact that guinea-pig's red blood ccrpuscles will not remove the 

 gastrotoxin from the serum by combining with it. 



