1912.] Trypanosomiasis and Yaws with Metallic Antimony. 205 



covering a period of from 17 to 20 days ; after an interval of six weeks 

 a short course of three doses extending over nine days has been given. 



The table on pp. 206-7 gives in shortest form the results of the treatment 

 with antimony alone. Thirty-five cases have been so treated : in 15 of 

 these there were no symptoms other than enlargement of the cervical glands, 

 except varying degrees of debility ; 17 had also fine tremor of the tongue and 

 five oedema of eyelids. The cases were not especially selected for treatment, 

 but were taken just as they came. 



Up to the present it has not been possible to procure susceptible animals 

 for inoculation from the cases treated, so microscopical examination has 

 been the only available method of controlling the results. Blood and gland 

 juice have been examined in all cases. Three observers have undertaken 

 each examination, and the total time of each examination has been one and 

 a half hours. Many of the cases have been repeatedly examined. 



Of these 35 cases four are dead and two have deserted. Try- 

 panosomes have reappeared in the blood of four cases and another has 

 relapsed clinically. The remaining 24 are all improved and all microscopical 

 examinations are negative up to date of writing. 



(a) Deaths. — Two only of the four deaths can be connected directly with 

 the treatment. Both were advanced cases and had been given larger doses 

 than usual. No. 2, a boy of 10 years, had 2 gr. on one occasion and 1| gr. 

 twice. He showed no symptoms till 48 hours after the last dose, when 

 meteorism appeared accompanied by acute abdominal pain, and he died 

 seven hours later. I have seen a somewhat similar death here in a case 

 treated only with atoxyl. 



No. 24 was also an advanced case ; he took two injections of 1 gr. without 

 discomfort and then had a dose of 2 gr. Twelve hours later epileptiform 

 symptoms set in quite suddenly ; the patient became unconscious and died 

 six hours later. 



Of the other two deaths — No. 7 was due to broncho-pneumonia ; the 

 patient ^was debilitated and broncho-pneumonia was very prevalent at that 

 time. No. 47 died from an epileptiform attack, but had not had any form of 

 treatment for a week. 



(b) Deserters. — One, No. 38, had recently completed his course of treat- 

 ment and had shown great improvement. The other, No. 3, belonged to 

 a district 100 miles from Yei. He had been without treatment for five 

 months and had done very well — taking large doses without untoward 

 symptoms. All examinations had been negative, though repeated very 

 frequently. 



(c) Relapses. — No. 27 is a clinical relapse. He was a soldier and his 



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