1912.] Trypanosomiasis and Yatvs with Metallic Antimony. 211 



11. Stomatitis : Two cases; one was vesicular, but the other was more 

 severe and ulcerated. In both cases the lesions were limited to the anterior 

 portion of the hard palate, and the condition may perhaps have been herpetic. 



It is of interest to note that very similar symptoms were observed in 

 experimental dogs treated in this manner. 



Short mention must be made of the effect of antimony on the temperature 

 and upon the leucocytes. 



I. Temperature. 



A "reaction thermique" has been described, occurring about 20 minutes after 

 injection of salts of antimony. This subject may be of greater interest 

 owing to the large amount of work done on the subject of salvarsan fever. 



Temperatures have been taken in over 100 cases : (1) at short intervals on 

 the day of an injection ; and (2) morning and evening temperatures for three 

 days after treatment. 



There is no effect on the temperature till two or three hours after treat- 

 ment, when it rises 1° F., and at four hours after treatment the average rise 

 is 1"4°F. The same evening, 10 to 12 hours after treatment, some cases 

 have fallen to normal, while others have gone up to over 101°. For the next 

 two days there is an average evening temperature of 100"2° and 99'7 , 

 and the temperature returns to normal. The results are identical in treated 

 and untreated cases ; trypanolysis and the disposal of dead trypanosomes do 

 not, therefore, cause this rise of temperature. 



The initial rise may be due to antimony, but the temperature for the two 

 following days is probably due to the saline solution. With the apparatus 

 available here it is impossible toj get pure distilled water ; it would be of 

 interest if some injections could be given with water twice distilled in a good 

 apparatus. 



The temperature does not seem to have any effect on the general condition 

 of the patients. 



II. Leucocytes. 



The action of leucocytes on this preparation has been described.* Blood 

 films, taken from animals after treatment, were stained and the leucocytes 

 found to be crammed with the minute particles of antimony. They show a 

 great avidity for this preparation, which they discharge, presumably in soluble 

 form, into the blood-stream, the action being thus spread over a longer 

 period. 



A series of 200 leucocyte counts has been made to determine the effect of 



* ' Eoy. Soc. Proc., : B, vol. 83, p. 140. 



