1913.] Contributions to the Biochemistry of Growth. 307 



which we have brought forward in the present paper points to the same 

 conclusions. 



Conclusions. 



Glycogen disappears more rapidly from the liver of tumour-bearing rats 

 than from the liver of a normal rat. Since observations on the gaseous 

 metabolism showed that there is no increased oxidation of carbohydrate 

 material in tumour-bearing animals, the results confirm the conclusion arrived 

 at previously from observations on pregnant animals, that in growth carbo- 

 hydrate material is used for the synthesis of protoplasm. 



The expenses of this research were defrayed by grants from the Moray 

 Fund of the University of Edinburgh. 



LITERATURE. 



1. W. Cramer, "The Gaseous Metabolism in Rats Inoculated with Malignant New 



Growths," 'Third Scientific Report of the Imperial Cancer Research Fund,' 1908, 

 p. 427. 



2. W. Cramer and H. Pringle, " The Nitrogen Metabolism of Rats bearing Malignant 



New Growths," ' Roy. Soc. Proc.,' 1910, B, vol. 82, p. 307. 



3. R. A. Chisholm, " The Respiratory Exchange of Mice bearing Transplanted 



Carcinoma," ' Journ. of Path, and Bact.,' 1911, vol. 15, p. 192. 



4. F. Medigreceanu, " Ergebnisse eines Futterungsversuches bei Ratten, die iiberimpfte 



Tumoren trugen," ' Berlin, klin. Wochenschft.,' 1910, No. 17. 



5. F. Medigreceanu, " On the Relative Sizes of the Organs of Rats and Mice bearing 



Malignant New Growths," 'Roy. Soc. Proc.,' 1910, B, vol. 82, p. 286. 



6. J. Lochhead and W. Cramer, "The Glycogenic Changes in the Placenta and the 



Foetus of the Pregnant Rabbit : a Contribution to the Chemistry of Growth," 

 'Roy. Soc. Proc.,' 1908, B, vol. 80, p. 263. 



