1913.] Metabolism in its Relation to the Thyroid Gland. 555 



would be more likely to affect the results when the animals are fed only once, 

 than when they are fed repeatedly with material from different animals. 



Table I.— Effect of Repeated Administration of Thyroid Gland on Rats. 



Exp. 



State of digestion. 



Dose of thyroid and length 

 of feeding. 



Liver glycogen 

 of thyroid-fed 

 animals. 



1 



Liver glycogen 

 of normal 

 controls. 



1 



2 

 3 

 4 

 5 

 6 

 7 



8 

 9 

 10 



11 



12 



Bread and milk ad lib. 



11 11 

 11 11 



3 hrs. after last meal . . . 



)! 11 

 11 11 



5 hrs. after last meal ... 



7 hrs. after last meal . . . 

 9 hrs. after last meal . . . 



J lobe every day for 5 days 

 a a 

 it a 

 £ lobe every day for 8 days 

 £ lobe every day for 5 days 

 £ lobe every day for 4 days 

 1 grm. dessic. gland on first 



day, 1 lobe fresh thyroid 



on second day 

 1 lobe every day for 2 days 



3) J) 



1 gram dessic. thyroid on 

 first day. 1 lobe fresh 

 thyroid on second day 



trace 

 it 



per cent. 



0- 49 



J. / L 



4-36 



1 -7 



4-2 

 2-8 



2-4 



1- 9 

 1-4 



0-5 

 0-6 



Table II. — Effect of Repeated Administration of Thyroid Gland on Cats. 



Exp. 



State of digestion. 



Dose of thyroid and length 

 of feeding. 



Liver glycogen 

 of thyroid-fed 

 animals. 



Liver glycogen 

 of normal 

 controls. 



l 



2 

 3 



4 

 5 



3 hrs. after last meal 



a it 



12 hrs. after last meal... 

 18 hrs. after last meal... 



1 lobe twice a day for 1 day 



1 lobe once a day for 2 days 

 3 lobes three times a day for 



1 day 



2 lobes on first day and 

 3 lobes the second day 



per cent, 

 trace 

 a 

 a 



0-37 

 trace 



per cent. 

 0-79 

 3 -03 

 3-88 



2-96 

 7-22 



Table III. — Effect of Single Administration of Thyroid on Rats. 



Expt. 



State of digestion. 



Dose of thyroid. 



Liver glycogen 

 of thyroid-fed 

 rats. 



Liver glycogen 

 of normal 

 controls. 



l 



2 

 3 

 4 



3 hrs. after last meal.. 

 6 hrs. after last meal.. 

 9 hrs. after last meal.. 

 11 hrs. after last meal.. 



1 lobe 17 hrs. previously .. 

 a a 

 a a 

 a a " 



per cent. 

 1-1 

 1-6 

 0-5 

 0-1 



per cent. 

 4-2 

 3-7 

 1 -8 



