﻿34 
  

  

  Dr. 
  A. 
  D. 
  Waller. 
  

  

  10m. 
  30 
  m. 
  J.k.5m. 
  ik.^Om. 
  40m. 
  Zh. 
  

  

  Fig. 
  2. 
  — 
  Morphia. 
  

  

  Experiment 
  4 
  : 
  Atropine. 
  — 
  As 
  soon 
  as 
  one 
  has 
  realised 
  that 
  the 
  emotive 
  

   reaction 
  is 
  a 
  true 
  fact, 
  one 
  thinks 
  of 
  the 
  action 
  of 
  sudo-motor 
  nerves, 
  and 
  

   tests 
  the 
  effect 
  of 
  atropine. 
  I 
  did 
  so 
  at 
  the 
  outset 
  of 
  my 
  experiments, 
  and, 
  

   being 
  familiar 
  with 
  the 
  sudo-motor 
  effects 
  demonstrable 
  on 
  the 
  cat's 
  foot, 
  as 
  

   well 
  as 
  with 
  their 
  prompt 
  abolition 
  by 
  atropine, 
  I 
  did 
  so 
  in 
  the 
  expectation 
  

   of 
  a 
  positive 
  result. 
  I 
  found 
  it 
  quite 
  impossible 
  to 
  persuade 
  myself 
  of 
  the 
  

   expected 
  result, 
  either 
  by 
  repeated 
  trial 
  and 
  simple 
  observation 
  of 
  the 
  

   galvanometric 
  spot 
  or 
  by 
  means 
  • 
  of 
  photographic 
  records. 
  By 
  simple 
  

   observation, 
  it 
  is 
  of 
  course 
  possible 
  to 
  arrive 
  at 
  a 
  wrong 
  conclusion 
  ; 
  the 
  

   response 
  varies 
  sufficiently 
  under 
  different 
  conditions 
  for 
  one 
  to 
  think 
  that 
  

   there 
  has 
  or 
  has 
  not 
  been 
  an 
  abolition 
  or 
  a 
  diminution 
  by 
  atropine. 
  I 
  have 
  

   therefore 
  taken 
  careful 
  records 
  of 
  the 
  palm 
  treated 
  by 
  local 
  application 
  of 
  

   belladonna 
  for 
  48 
  hours, 
  followed 
  by 
  hypodermic 
  injection 
  of 
  atropine, 
  

   with 
  the 
  usual 
  general 
  effects, 
  dilatation 
  of 
  pupil, 
  dryness 
  of 
  the 
  mouth, 
  

   high-pulse 
  frequency, 
  headache 
  and 
  nausea 
  without 
  producing, 
  as 
  far 
  as 
  I 
  

   could 
  see, 
  the 
  slightest 
  effect 
  upon 
  the 
  emotive 
  response. 
  My 
  observations 
  

   have 
  not 
  been 
  very 
  numerous 
  — 
  about 
  twenty 
  in 
  all 
  — 
  but 
  the 
  most 
  recent 
  of 
  

   them 
  have 
  been 
  as 
  thorough 
  as 
  I 
  thought 
  justifiable 
  upon 
  the 
  human 
  subject, 
  

   and 
  at 
  the 
  conclusion 
  of 
  the 
  last 
  trial 
  I 
  decided 
  not 
  to 
  repeat 
  it. 
  In 
  the 
  

   face 
  of 
  the 
  statements 
  of 
  other 
  observers, 
  it 
  is 
  useless 
  to 
  assert 
  that 
  atropine 
  

   has 
  no 
  effect 
  upon 
  the 
  emotive 
  reaction, 
  and 
  I 
  shall 
  content 
  myself 
  with 
  the 
  

   statement 
  that 
  I 
  have 
  failed 
  to 
  observe 
  it, 
  and 
  that 
  I 
  have 
  recorded 
  

   instances 
  where 
  it 
  remained, 
  and 
  was 
  apparently 
  of 
  normal 
  magnitude 
  in 
  a 
  

   subject 
  presenting 
  the 
  usual 
  signs 
  and 
  symptoms 
  of 
  atropine 
  poisoning. 
  

  

  I 
  shall 
  not 
  venture 
  to 
  assert 
  that 
  atropine, 
  in 
  larger 
  dose 
  than 
  I 
  care 
  to 
  

   employ, 
  like 
  any 
  other 
  powerful 
  toxic 
  agent, 
  such 
  as 
  morphia 
  or 
  chloroform, 
  

   will 
  not 
  abolish 
  the 
  emotive 
  response. 
  My 
  statement 
  is 
  limited 
  to 
  the 
  

   specific 
  effect 
  of 
  a 
  small 
  dose. 
  

  

  