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  The 
  Genesis 
  of 
  (Edema 
  in 
  Beriberi. 
  

  

  By 
  Robert 
  McCarrison, 
  M.D., 
  D.Sc, 
  F.R.C.P., 
  Brevet 
  Lieutenant-Colonel, 
  

  

  Indian 
  Medical 
  Service. 
  

  

  (Communicated 
  by 
  Prof. 
  J. 
  G. 
  Adami, 
  F.R.S. 
  — 
  Received 
  June 
  19, 
  1919.) 
  

  

  In 
  a 
  previous 
  communication 
  (1) 
  it 
  was 
  shown 
  : 
  (1) 
  that 
  in 
  avian 
  beriberi 
  

   (polyneuritis 
  gallinarum) 
  oedema 
  was 
  constantly 
  (100 
  per 
  cent.) 
  associated 
  

   with 
  massive 
  enlargement 
  of 
  the 
  adrenal 
  glands 
  ; 
  (2) 
  that 
  82.2 
  per 
  cent, 
  of 
  

   cases 
  having 
  such 
  enlargement 
  of 
  the 
  adrenal 
  glands 
  presented 
  evidences 
  of 
  

   oedema 
  in 
  some 
  form 
  ; 
  (3) 
  that 
  the 
  enlargement 
  of 
  the 
  adrenals 
  was 
  associated 
  

   with 
  a 
  corresponding 
  increase 
  in 
  the 
  adrenalin-content, 
  as 
  determined 
  by 
  

   physiological 
  means. 
  Additional 
  evidence 
  confirmatory 
  of 
  these 
  findings 
  is 
  

   recorded 
  in 
  the 
  present 
  paper. 
  

  

  Avian 
  beriberi 
  was 
  produced 
  experimentally 
  in 
  a 
  fourth 
  series 
  of 
  22 
  

   young 
  pigeons 
  by 
  means 
  of 
  a 
  dietary 
  of 
  autoclaved 
  milled 
  rice 
  (2 
  and 
  3). 
  

   Detailed 
  post-mortem 
  examinations 
  were 
  made 
  in 
  all 
  cases. 
  The 
  heart's 
  blood 
  

   was 
  examined 
  by 
  aerobic 
  cultural 
  methods 
  for 
  bacterial 
  organisms. 
  Ten 
  of 
  

   the 
  22 
  cases 
  presented 
  evidences 
  of 
  oedema 
  (Tables 
  II 
  and 
  III). 
  

  

  The 
  adrenal 
  glands 
  were 
  removed, 
  weighed, 
  and 
  the 
  adrenalin-content 
  

   immediately 
  estimated 
  by 
  the 
  method 
  of 
  Folin, 
  Cannon, 
  and 
  Dennis 
  (4). 
  

   Similar 
  estimations 
  were 
  made 
  of 
  the 
  adrenalin-content 
  of 
  the 
  adrenals 
  in 
  

  

  