﻿126 
  

  

  Dr. 
  H. 
  H. 
  Dale. 
  

  

  LITERATURE. 
  

  

  Boycott 
  and 
  Haldane 
  (1908), 
  ' 
  Journal 
  of 
  Physiology,' 
  vol. 
  37, 
  p. 
  355. 
  

  

  Chapman 
  and 
  Wardlaw 
  (1916), 
  ' 
  Medical 
  Journal 
  of 
  Australia,' 
  p. 
  387. 
  

  

  Cook 
  and 
  Pembrey 
  (1913), 
  ' 
  Journal 
  of 
  Physiology,' 
  vol. 
  14, 
  p. 
  429. 
  

  

  Haldane 
  (1905), 
  ' 
  Journal 
  of 
  Hygiene,' 
  vol. 
  5, 
  p. 
  494. 
  

  

  Haldane 
  and 
  Fitzgerald 
  (1905), 
  ' 
  Journal 
  of 
  Physiology,' 
  vol. 
  32, 
  p. 
  486. 
  

  

  Haldane 
  and 
  Priestley 
  (1916), 
  'Journal 
  of 
  Physiology,' 
  vol. 
  1, 
  p. 
  296. 
  

  

  Hill 
  and 
  Flack 
  (1909), 
  ' 
  Proc. 
  Physiol. 
  Soc.,' 
  March 
  27 
  (' 
  Journal 
  of 
  Physiology,' 
  vol. 
  38). 
  

  

  Hunt 
  (1912), 
  'Journal 
  of 
  Hygiene,' 
  vol. 
  12, 
  p. 
  479. 
  

  

  Harvey-Sutton 
  (1908), 
  'Journal 
  of 
  Path, 
  and 
  Bact.,' 
  vol. 
  13. 
  

  

  Griffith-Taylor 
  (1918), 
  " 
  The 
  Australian 
  Environment," 
  ' 
  Advisory 
  Council 
  of 
  Science 
  and 
  

   Industry. 
  Memoir 
  1,' 
  Melbourne, 
  p. 
  117. 
  

  

  Croonian 
  Lecture. 
  — 
  The 
  Biological 
  Significance 
  of 
  

   Anaphylaxis. 
  

   By 
  H. 
  H. 
  Dale, 
  C.B.E., 
  M.D., 
  F.RS. 
  

  

  (Lecture 
  delivered 
  May 
  29, 
  1919.— 
  MS. 
  received 
  October 
  21, 
  1919.) 
  

  

  Me. 
  President, 
  Ladies, 
  and 
  Gentlemen, 
  — 
  I 
  am 
  deeply 
  sensible 
  of 
  the 
  

   honour 
  conferred 
  upon 
  me 
  by 
  the 
  invitation 
  to 
  deliver 
  the 
  Croonian 
  Lecture 
  

   before 
  this 
  Society. 
  In 
  conveying 
  that 
  invitation 
  the 
  Council 
  did 
  me 
  the 
  

   further 
  service 
  of 
  indicating 
  a 
  desire 
  that 
  the 
  lecture 
  should 
  deal 
  with 
  " 
  The 
  

   Biological 
  Significance 
  of 
  Anaphylaxis." 
  From 
  the 
  wording 
  of 
  the 
  title 
  thus 
  

   suggested, 
  and 
  from 
  their 
  choice 
  to 
  deal 
  with 
  this 
  subject 
  of 
  one 
  whose 
  own 
  

   activities 
  have 
  lain 
  outside 
  the 
  conventional 
  limits 
  of 
  immunological 
  study, 
  

   I 
  gather 
  that 
  the 
  Council's 
  intention 
  was 
  that 
  the 
  lecture 
  should 
  deal 
  with 
  

   the 
  interest 
  of 
  the 
  phenomena 
  of 
  anaphylaxis 
  for 
  a 
  wider 
  field 
  of 
  biological 
  

   enquiry 
  than 
  that 
  to 
  which 
  their 
  investigation 
  primarily 
  belongs. 
  

  

  Tou 
  will 
  not 
  expect 
  or 
  desire 
  that 
  I 
  shall 
  attempt 
  a 
  detailed 
  review 
  of 
  the 
  

   enormous 
  literature 
  which 
  has 
  grown 
  up, 
  with 
  almost 
  unique 
  luxuriance, 
  

   round 
  the 
  study 
  of 
  anaphylaxis. 
  I 
  shall 
  deal 
  with 
  the 
  history 
  of 
  the 
  investi- 
  

   gation 
  in 
  summary 
  fashion, 
  mentioning 
  few 
  of 
  the 
  participants 
  by 
  name, 
  and 
  

   giving 
  only 
  such 
  broad 
  outlines 
  as 
  will 
  serve 
  to 
  make 
  clear 
  the 
  nature 
  of 
  the 
  

   problem 
  to 
  any 
  who 
  may 
  be 
  imperfectly 
  familiar 
  with 
  it. 
  In 
  presenting 
  

   some 
  of 
  my 
  own 
  experiments 
  in 
  somewhat 
  fuller 
  detail, 
  I 
  am 
  guided 
  by 
  what 
  

   I 
  believe 
  to 
  be 
  the 
  Council's 
  desire, 
  that 
  I 
  should 
  put 
  before 
  you 
  a 
  personal 
  and 
  

   individual 
  view, 
  rather 
  than 
  embark 
  on 
  the 
  hopeless 
  endeavour 
  to 
  compress 
  

  

  