﻿The 
  Biological 
  Significance 
  of 
  Anaphylaxis. 
  

  

  137 
  

  

  demonstrate 
  practically 
  all 
  the 
  characteristic 
  phenomena 
  of 
  active 
  and 
  

   passive 
  anaphylaxis.* 
  

  

  Fig. 
  1 
  illustrates 
  the 
  exquisite 
  specificity 
  of 
  the 
  reaction 
  as 
  exhibited 
  by 
  

   this 
  method. 
  The 
  uterine 
  horn 
  from 
  a 
  guinea-pig 
  rendered 
  sensitive 
  by 
  an 
  

   injection 
  of 
  T 
  ^ 
  c.c. 
  of 
  horse 
  serum, 
  given 
  14 
  days 
  previously, 
  was 
  suspended 
  

   in 
  250 
  c.c. 
  of 
  Einger's 
  solution 
  at 
  37° 
  C:, 
  to 
  which, 
  at 
  A, 
  B, 
  C, 
  D, 
  E, 
  and 
  F, 
  

   were 
  added 
  in 
  succession 
  doses 
  of 
  - 
  l 
  c.c. 
  of 
  the 
  sera 
  from 
  sheep, 
  cat, 
  rabbit, 
  

   dog, 
  and 
  man, 
  and 
  of 
  egg-white. 
  None 
  of 
  these 
  substances 
  had 
  any 
  effect. 
  

   Finally, 
  at 
  G, 
  01 
  c.c. 
  of 
  horse 
  serum 
  was 
  added, 
  and 
  the 
  uterine 
  muscle 
  at 
  

   once 
  responded 
  with 
  maximal 
  tonus. 
  

  

  Fig. 
  2 
  is 
  taken 
  from 
  a 
  similar 
  experiment, 
  in 
  which 
  the 
  guinea-pig 
  had 
  

   been 
  made 
  sensitive 
  by 
  an 
  injection 
  of 
  egg-white. 
  - 
  5 
  c.c. 
  of 
  horse 
  serum, 
  at 
  

   A, 
  is 
  in 
  this 
  case 
  without 
  effect 
  ; 
  - 
  l 
  c.c. 
  of 
  egg-white, 
  at 
  B, 
  causes 
  a 
  maximal 
  

   response. 
  

  

  Fig. 
  1. 
  Fig. 
  2. 
  

  

  Fig. 
  1 
  (from 
  ' 
  Journ. 
  Pharmacol, 
  and 
  Exp. 
  Therap.,' 
  vol. 
  4, 
  p. 
  214). 
  

   Fig. 
  2 
  (from 
  'Journ. 
  Pharmacol, 
  and 
  Exp. 
  Therap.,' 
  vol. 
  4, 
  p. 
  180). 
  

  

  Fig. 
  3 
  is 
  taken 
  from 
  one 
  of 
  a 
  large 
  number 
  of 
  experiments 
  in 
  which 
  an 
  

   attempt 
  was 
  made 
  to 
  eliminate 
  the 
  possibility 
  of 
  a 
  participation 
  in 
  the 
  

   phenomenon 
  by 
  traces 
  of 
  blood 
  or 
  serum 
  left 
  in 
  the 
  vessels 
  of 
  the 
  excised 
  

   plain 
  muscle. 
  The 
  blood 
  vessels 
  of 
  the 
  uterus 
  were 
  continuously 
  perfused 
  

   with 
  Ringer's 
  solution 
  for 
  an 
  hour 
  before 
  the 
  organ 
  was 
  removed 
  from 
  the 
  

   body. 
  The 
  delicacy 
  and 
  specificity 
  of 
  the 
  response 
  are 
  thereby 
  in 
  no 
  degree 
  

   impaired. 
  The 
  plain 
  muscle, 
  from 
  a 
  guinea-pig 
  sensitive 
  to 
  a 
  horse-serum, 
  is 
  

   indifferent 
  to 
  cat 
  and 
  sheep 
  serum, 
  added 
  at 
  A 
  and 
  B, 
  but 
  responds 
  

   maximally 
  to 
  - 
  l 
  c.c. 
  of 
  horse 
  serum 
  at 
  C. 
  

  

  * 
  'Journ. 
  Pharmacol, 
  and 
  Exp. 
  Therap.,' 
  vol. 
  4, 
  p. 
  167 
  (1912). 
  

  

  