﻿The 
  Biological 
  Significance 
  of 
  Anaphylaxis. 
  139 
  

  

  again 
  desensitized, 
  and 
  fails 
  to 
  respond 
  to 
  a 
  further 
  dose 
  (F). 
  The 
  dose 
  in 
  

   each 
  case 
  was 
  0"05 
  c.c. 
  of 
  horse-serum. 
  

  

  The 
  uterine 
  plain 
  muscle 
  of 
  a 
  normal 
  guinea-pig 
  can 
  be 
  rendered 
  sensitive 
  

   by 
  prolonged 
  perfusion 
  with 
  serum 
  from 
  sensitive 
  or 
  immune 
  animals. 
  The 
  

   sensitiveness 
  is 
  barely 
  perceptible 
  after 
  perfusion 
  for 
  one 
  hour 
  (fig. 
  8), 
  but 
  

  

  Fig. 
  7. 
  Fig. 
  8. 
  

  

  Fig. 
  5 
  (from 
  ' 
  Journ. 
  Pharmacol, 
  and 
  Exp. 
  Therap.,' 
  vol. 
  4, 
  p. 
  196). 
  

  

  Figs. 
  6 
  and 
  7 
  (from 
  ' 
  Journ. 
  Pharmacol, 
  and 
  Exp. 
  Therap.,' 
  vol. 
  4, 
  pp. 
  198, 
  199). 
  

  

  Fig. 
  8 
  (from 
  'Journ. 
  Pharmacol, 
  and 
  Exp. 
  Therap.,' 
  vol. 
  4, 
  p. 
  205). 
  — 
  I. 
  Control 
  horn 
  of 
  

  

  normal 
  uterus. 
  II. 
  Second 
  horn 
  of 
  same 
  after 
  perfusion 
  for 
  one 
  hour 
  with 
  20 
  per 
  

  

  cent, 
  anaphylactic 
  serum. 
  At 
  A 
  and 
  B 
  0'5 
  c.c. 
  horse 
  serum. 
  

  

  clearly 
  developed 
  after 
  five 
  hours 
  (fig. 
  9). 
  This 
  corresponds 
  with 
  observa- 
  

   tions 
  on 
  the 
  living 
  guinea-pig, 
  in 
  which 
  sensitiveness 
  cannot 
  be 
  detected 
  until 
  

   some 
  six 
  hours 
  after 
  antibody 
  from 
  another 
  animal 
  has 
  been 
  injected 
  into 
  the 
  

   circulation. 
  

  

  In 
  the 
  literature 
  of 
  anaphylaxis 
  much 
  confusion 
  has 
  been 
  caused 
  by 
  the 
  use 
  

   of 
  the 
  inelegant 
  term 
  " 
  antianaphylaxis 
  " 
  for 
  two 
  entirely 
  different 
  conditions. 
  

   We 
  have 
  seen 
  that 
  the 
  plain 
  muscle 
  exposed 
  to 
  an 
  effective 
  dose 
  of 
  antigen 
  

  

  