﻿The 
  Biological 
  Significance 
  of 
  Anaphylaxis. 
  145 
  

  

  13 
  days 
  previously. 
  At 
  A 
  and 
  B 
  doses 
  of 
  1 
  mgrm. 
  and 
  10 
  mgrm. 
  respectively, 
  

   of 
  the 
  corresponding 
  pseudo-globulin 
  were 
  added 
  to 
  the 
  bath. 
  At 
  C 
  10 
  mgrm. 
  

   of 
  the 
  euglobulin 
  were 
  similarly 
  added, 
  and 
  the 
  same 
  again 
  at 
  D. 
  But 
  the 
  

   cases 
  of 
  greatest 
  interest, 
  as 
  presenting 
  the 
  greatest 
  difficulty 
  of 
  interpretation, 
  

   were 
  those 
  in 
  which 
  antigenic 
  difference 
  could 
  not 
  hitherto 
  be 
  related 
  to 
  any 
  

   chemical 
  or 
  physical 
  difference, 
  but 
  in 
  which 
  an 
  indication 
  of 
  stereochemical 
  

  

  Fig. 
  13 
  (from 
  ' 
  Biochem. 
  Journ.,' 
  vol. 
  13, 
  p. 
  255, 
  1919). 
  — 
  Second 
  horn 
  of 
  uterus 
  from 
  same 
  

  

  guinea-pig 
  as 
  fig. 
  12. 
  

  

  Fig. 
  14 
  (from 
  ' 
  Biochem. 
  Journ.,' 
  vol. 
  10, 
  p. 
  422, 
  1916). 
  

  

  difference 
  is 
  now 
  obtained. 
  What 
  may 
  be 
  the 
  nature 
  of 
  the 
  relation 
  between 
  

   the 
  antibody 
  and 
  the 
  antigen, 
  in 
  what 
  way 
  the 
  antibody 
  is 
  adjusted 
  to 
  form 
  a 
  

   complex 
  only 
  with 
  a 
  protein 
  of 
  a 
  certain 
  molecular 
  pattern, 
  are 
  points 
  on 
  

   which 
  I 
  believe 
  no 
  chemist 
  would 
  hazard 
  a 
  suggestion 
  at 
  the 
  present 
  stage. 
  

   The 
  relation 
  of 
  enzyme 
  to 
  substrate, 
  the 
  symbol 
  of 
  lock 
  and 
  key 
  suggest 
  

   themselves 
  ; 
  but 
  the 
  lock 
  must 
  be 
  much 
  more 
  complicated, 
  the 
  pattern 
  of 
  the 
  

   key 
  much 
  more 
  intricate 
  than 
  any 
  for 
  which 
  a 
  study 
  of 
  enzymes 
  will 
  provide 
  

  

  