1912.] 



A Critical Study of Experimental Fever. 



183 



due to injection of extract of red cells of the same species. The same result 

 followed the injection of red-cell extract of another species, as well as that of 

 red-cell extract made from the cells of the animal injected. In all cases 

 where fever resulted the water used for the preparation of the extracts was 

 the same and contained 40 organisms per c.c. on injection. The water 

 employed in the preparation of the sodium citrate solutions into which the 

 blood was shed, the saline in which the cells were washed, and for lysis of the 































Chart 10 

























































































/ 





















X 























A. Babbit, 2785 grm., injected intravenously with red-cell extract in water containing 



F.P.B. Injection ratios of water and extract same as in B (figures lost). 



B. Babbit, 2370 grm., injected intravenously with red-cell extract in water containing no 



F.P.B. Injection ratios of water and extract same as in A. 

 (For details of preparation of extract, vide text. Intervals between observations, 

 30 minutes.) 



blood corpuscles was a sample containing F.P.B. , and 40 organisms per c.c. 

 The control extracts were made throughout with solutions containing pure 

 water. The extent of fever shown is in excess of that which follows injection 

 of a similar quantity of water containing F.P.B. This increase is perhaps 

 due to absorption of F.P.B. during preparation of the extracts, perhaps to 

 the action of F.P.B. on the stromata resulting in their acquisition of pyro- 

 genetic function not previously possessed. The point requires quantitative 

 investigation. 



