184 Messrs. E. C. Hort and W. J. Penfold. [Feb. 17, 



Chart 11 shows that the injection of fresh normal serum produces a fall of 

 temperature, in spite of the presence of fibrin ferment. This fact gravely 

 affects the theory of fibrin ferment fever (17-22) more especially as all the 

 evidence hitherto accepted in support of this theory is based on injection 

 of extracts in water that we now know to have been liable to contamination 

 with F.P.B. Until, therefore, these experiments on ferment fever, including 

 fibrin ferment fever, have been repeated with extracts in water proved to be 

 free from this substance all observations on this subject require careful 

 scrutiny. 



A. Rabbit, 2211 grm., injected intravenously with 3 c.c. normal serum from another 



healthy rabbit. Injection 4 hours after separation. Injection ratio, 1/737. 



B. Rabbit, 1932 grm., injected intravenously with 3"50 c.c. of his own serum. Injection 



4 hours after separation. Injection ratio, 1/552. 



(Interval between observations, 30 minutes.) 



With regard to Charts 9, 10, 11 as a group it is generally believed that the 

 injection of sterile extracts of animal tissues (23-25) may cause fever. This 

 applies to extracts of foreign blood, of red cells, of leucocytes, or of blood 

 serum, as well as to extracts of all foreign tissues. By the term foreign tissue 

 is here meant tissue alien to the animal injected, even if belonging to animals 

 of the same species. Fever is also believed to follow the injection of an 

 animal with extracts of his own blood or blood cells, and the fever following 

 fracture and luematomata have been thus explained. In all experiments, 

 however, the extracts were prepared in liquids containing water which must 

 now be regarded as suspect. In view of our experiments the value of much 

 of the evidence, therefore, on which belief in this type of fever rests disappears. 

 If reference be made to Charts 1, 2, 3 in the light of Charts 9, 10, 11 it will 

 be seen that they afford additional evidence that the theory of tissue fever 

 cannot be supported by lysis of cells effected by the injection of distilled 

 water. We find this to be also true of extracts of solid organs, including the 

 brain. The injection of fresh egg albumen also failed in our hands to give 



