1912.] 



A Critical Study of Experimental Fever. 



185 



rise to fever, a fact that has some bearing on the belief in protein fever after 

 single injections of this class of substance in an unbroken state. 



In conclusion, we submit that the existence of "water-fever," " salt-fever," 

 " sugar-fever," " ferment-fever," and " tissue-fever " no longer rests on secure 

 ground. That future advance in the study of fever is only possible by 

 recognition of all the fallacies inherent to experiments involving the use of 

 water liable to contamination with this fever-producing substance will not, 

 we believe, be questioned. 



The fact that one of us has been a victim to these fallacies is sufficient 

 justification for the critical nature of this note. 



REFERENCES. 



1. Kottmann, " Bestiinmung der Blutmenge b. Menschen u. Tier," ' Arch. Exp. Pathol. 



u. Pharmak.,' 1906, vol. 54, p. 375. 



2. Schaps, " Saltz u. Zucker Injektion b. Sauglin.," ' Berl. Klin. Woch.,' 1907, No. 19. 



3. Bergmann, E., " Ueber das chirch Faulniss u. Entziindproducte erzeugte Fieber." 



' Petersburg Med. Zeitsch.,' 1868, p. 16. 



4. Hort, E. C, " Autotoxsemia and Infection," ' Roy. Soc. Proc.,' 1910, vol. 82. 



5. Hort and Penfold, "The Dangers of Saline Injections," 'Brit. Med. Journ., 



December 16, 1911, p. 1510. 



6. Wechselmann, "Neuere Erfahrungen uber intrav. Salvarsan-Injektion ohne Reactions- 



Erscheinungen," ' Munch. Med. Woch.,' July 11, 1911, u. April, 1911, p. 1510. 



7. Sahli, "Ueber Auswaschung d. Menschlichen Organism, u. uber d. Werth u. die 



Methoden d. Wasserzufuhr in Krank.," 'Corresp. Bl. d. Schweiz. Aerzte,' 1890, 

 Jg. xx, 9, 545. 



8. Hutinel, " Les effets des Injections sous-cutanees chez ies Enfants Tuberculeux," 



' Semaine medicale,' 1895, p. 117. 



9. Wiener, " Die Injektionstherapie der Neuralgien mit Beriicksichtigung des Koch- 



salzfiebers," ' Munch. Med. Woch.,' 1910, p. 437. 



10. Bingel, " Uber Salz- u. Zucker-fieber," ' Arch. Exp. Path. u. Pharm.,' 1911, vol. 64, p. 1. 



11. Freund, H., and Graefe, E., " Stoffwecbseluntersuchungen b. Exp. Kochsalzfieber," 



' Arch. Exp. Path. u. Pharmak.,' December, 1911, p. 55. 



12. Mollhausen, " Salz- u. Zuckerinfusionen b. Saugling.," ' Jahrbuch f . Kinderheil,' 1907, 



vol. 65, p. 516. 



13. Freund, " Kochsalzfieber," ' Arch. Exp. Path. u. Pharmak.,' 1911, vol. 65, p. 225. 



14. Davidsohn and Friedemann, " Untersuchungen iiber das Salzfieber bei normalen u. 



anaphylactischen Kaninchen," 'Arch. f. Hygiene,' 1909, vol. 71, p. 9. 



15. Finkelstein, "Ueber Aliment Fieber," 'Deutsch. Med. Woch.,' 1909, p. 191. 



16. Voit, ' Untersuchungen iiber das Verhalten verschiedener Zuckerarten ini Menschlichen 



Organism, nach subeut. Injection," ' Deutsch. Arch. klin. Med.,' 1897, vol. 58, p. 523. 



17. Edelberg, 'Arch. Exp. Pathol, u. Pharmak.,' vol. 12. 



18. Mendelsohn, " Ueber d. Function, d. Niere im Fieber," ' Virch. Archiv,' 1885, 



vol. 100, p. 274. 



19. Hildebrand, " Zur Kentniss d. physiol. Wirkung der hydrolytischen Fermente," 



' Virch. Archiv,' 1890, vol. 121, p. 1. 



20. Hildebrand, "Ueber einige pyretische Versuch.," 'Virch. Archiv,' 1893, vol. 131, p. 3. 



21. Bergmann and Angerer, ' Wurzburger Festschrift.' 



VOL. LXXXV. — B. O 



