1912.] On the Nature of Pancreatic Diabetes. 219 



conditions, i.e. working at a normal arterial pressure and with, a normal 

 output. In this preparation we are able to vary at will the venous filling of 

 the heart, the arterial resistance, or the temperature. The total amount of 

 blood employed is about 300 c.c, and as the heart of a small dog puts out 

 about 150 to 250 c.c. of blood per minute, the whole of the blood in the 

 apparatus circulates through the heart once in every two minutes. It 

 occurred to us that it might be possible by using this preparation to throw 

 light on the pathogeny of pancreatic diabetes. 



I. The Consumption of Bwjar in the Normal Heart. 



The power of the tissues to utilise glucose directly was asserted by 

 Chauveau and Kaufmann (3) in the case of voluntary muscle, and has been 

 proved in the case of the heart transfused with Einger's fluid, by Locke and 

 Eosenheim (4), and by Eohde (5) and others. In our experiments, a small 

 proportion of glucose having been added to the blood, it was allowed to 

 circulate through the heart at a temperature of 37° C. continuously 

 for two to three hours. The arterial pressure was kept throughout at 

 80 to 90 mm. Hg. The following table represents some of the results 

 obtained : — 



Consumption of Sugar by the Heart. 

 A. Normal Heart Fed with Normal Blood. 





First period (1 hr.). 



Second period (1 hr.). 





Sugar in blood. 



Milligrammes 



Sugar i 





Milligrammes 







After. 



sugar per grm. 

 heart.* 





After. 



sugar per grm. 



Dog 



Cat 



per cent. 

 0-79 

 0-70 

 0-20 

 0-58 

 0-72 



per cent. 

 0-66 

 0-61 

 0-11 

 0-51 

 0-65 



5 -8 

 4-8 



3- 9 



4- 2 



5- 1 



per cent. 

 0-66 

 0-61 

 0-32 



per cent. 

 0-59 

 0-56 

 0-25 



5-6 

 3-5 

 3-5 





Sugar in serum. 









Dog 



■ 



per cent. 

 0-63 

 0-81 

 0-89 



per cent. 

 0-50 

 0-69 

 0-71 



4- 1 



3-5 



5- 15 



per cent. 

 0-50 

 0-69 



per cent. 

 0*33 

 0-57 



4-1 



2-8 



* This column was calculated after determining the total volume of blood in circulation and 

 the weight of the heart. 



Q 2 



