12 



Mr. C. H. Kellaway. The Effect of Certain 



weight more rapidly than the artificially fed birds of Series 2. As under 

 these conditions they were largely living on their own tissues, they may have 

 derived thence an amount of accessory substance sufficient to delay the 

 appearance of polyneuritis. 



In Series 2 the average weight of the adrenals was 172"0 mgrm., and of the 

 adrenaline 0'356 mgrm. per kilogramme of the original body weight. In 

 Series 3 these figures were 108"7 mgrm. and 0'261 mgrm. The corresponding- 

 figures for the first group of normal pigeons given in Table II were 

 79'1 mgrm. and 0'160 mgrm. The results from these normal pigeons cannot, 

 however, be regarded as strictly controlling this experiment so far as the 

 content of adrenaline in the suprarenals is concerned, since the birds which 

 gave them had not been caged for the same length of time as those fed 

 on rice. 



This experiment, and all subsequent ones, confirmed McCarrison's findings 

 in regard to adrenal hypertrophy in avian polyneuritis. The figures obtained 

 for the store of adrenaline in this experiment, though nearly double those 

 yielded by normal birds investigated at the same time, were not nearly so 

 high as those obtained later in otiier normal birds. This, in itself, seemed to 

 indicate that changes in the adrenaline-content of the suprarenals are not 

 necessarily of importance in the development of avian polyneuritis. Further 

 evidence in this direction was supplied by later observations. 



A further series of six pigeons which were fed with polished rice, and 

 which were killed for analysis at the same time as Series 11, in Table II 

 showed a large increase in the store of adrenaline when compared with the 

 normal birds, which iu this case provided an accurate control. 



The results of this series are given iu full in Table IV. 



Table IV. — Series 12. Pigeons Fed on Polished Eice. 



Dis- 

 tinguishinn; 

 number. 



Number 



of 

 clays on 

 diet. 



Initial 

 weight 



in 

 grm. 



Final 

 weight 

 in 

 grm. 



Weight 

 of 



adrenals 

 in mgrm. 



Weight of 

 adrenals 

 per kilog. 

 of original 



weight 

 in mgrm. 



Weight 

 of 



adrenaliue 

 in mgrm. 



Weight of 

 adrenaline 



per kilog. 

 of original 

 weight 



in mgrm. 







32 



270 



238 



45 



166-7 



0-168 



-622 



1 



32 



310 



257 



35 



112 -9 



0-126 



0-406 



2 



19 



310 



247 



48 



154-8 



-240 



0-774 



3 



32 



320 



259 



41 



128-1 



199 



-622 



4 



28 



300 



270 



52 



173-3 



0-167 



0-557 



5 



31 



310 



265 



66 



212-9 



0-161 



0-519 



! 



Average ...j — 



303 



256 



48 



158 -4 



0-177 



0-584 



