Destiny of Cholesterol in the Animal Organism. 367 



In the paper already referred to (" On the Composition of the Unsaponifiable 

 Matter of the Ether Extract of Human FjEces ") Gardner suggested two 

 sources for these non-precipitable oils: (1) the -substances which accompany 

 cholesterol in the unsaponifiable matter of tissue fat ; (2) the bile acids or 

 their derivatives. With regard to the first source, it is clear from the figures 

 in Table II that the quantity taken in with the food would fully account for 

 that in the fasces. This, however, cannot be decided until the unsaponifiable 

 matter of the tissue fats has been thoroughly investigated and compared with 

 that of the faeces. With regard to the second source, probably oxidisation 

 experiments will throw light on this. Preliminary experiments, however, 

 proved inconclusive. 



Work is being continued in both these directions, and we hope to have the 

 honour of communicating the results at some future time. 



We take this opportunity of thanking the Grant Committee of the Royal 

 Society for help in defraying the expenses of this work. 



EEFEEENCES. 



Ellis and Gardner (1912—1), 'Eoy. Soc. Proc.,' B, vol. 86, p. 13. 

 Ellis and Gardner (191 2—2), ' Eoy. Soc. Proc.,' B, vol. 85, p. 392. 

 <]rardner and Lander (1913), ' Biochem. Journ.,' vol. 7, p. 577. 

 Gardner and Fox (1919), ' Biochem. Journ.,' vol. 13, p. 368. 

 Gardner and Fox (1921), 'Biochem. Journ.,' vol. 15, p. 376. 

 Gardner (1921), ' Biochem. Journ.,' vol. 15, p. 244. 

 Peirce (1912), ' Deutsch. Arch. f. Klin. Med.,' vol. 106, p. 337. 

 PfafiFand Balch (1897), 'Journ. of Expt. Medicine,' vol. 2, p. 44. 



""Eeport on the Digestibility of Breads (1918)," 'Publications of the Eoyal Society Food 



(War) Committee,' [3206]. 

 Widal, Weil and Laudet (1912), ' Semaine M6dicale,' vol. 32, p. 529. 



