1908.] Destiny of Cholesterol in the Animal Organism. 127 



Table III. 



Experi- 

 ment. 



"Weight of 

 dog, in 

 kilo- 

 grammes. 



Diet. 



Diet 

 period, in 

 days. 



Weight of 

 blood, in 

 grammes. 



Weight of 

 cholesterol 

 in the 

 blood. 



Per- 

 centage of 

 cholesterol 

 in the 

 blood. 





A. — Animals killed two to four 



hours after a meal. 



(Terriers.) 



XII. 



7-36 



Bread, egg-white, cream 



10 



480 



-3892 



-0811 



XIII. 



8-13 





9 



430 



-3872 



0-0900 



XIV. 



9-77 



Meal 



9 



680 



-5420 



-0797 





B- 



-Animals killed twenty-four hours after a meal. 





XVI* 



7-8 



Meal 



7 



524 



-4350 



'083 



XVII.f 



9-1 





14 



507 



-7526 



0-148 



XVIII.t 



19 -2 



Raw brain + bread 



24 



1140 



-8160 



0-072 



XIX.? 



12 -67 



Bread, egg-white, cream 



10 



760 



-8132 



0-107 



* Terrier. t Terrier ; dog jaundiced. 



X Retriever dog. § Collie dog. 



influence of food on the excretion of bile, but from experiments that have 

 been made by various observers there is good reason to suppose that the 

 nature of the diet would not be without influence. Furthermore, the dog is 

 a discontinuous feeder and the flow of bile into its intestine would be 

 intermittent. Under these circumstances the portion of the floating (as 

 distinguished from the constitutional) cholesterol in the blood due to the 

 reabsorption of the cholesterol of the bile, would not necessarily be strictly 

 comparable in these different cases. As to what would be the limits of such 

 variation, if any, we have no data at present from which to form an opinion^ 

 but a variation of the kind suggested might wholly or partially mask any 

 variation due to the cholesterol absorbed from the food, which, at best, would 

 not be great in absolute magnitude. In the first series of experiments (A) 

 in which the animals are fairly comparable in weight and variety, the blood 

 of the dog fed on brain shows a small increase in the percentage of 

 cholesterol in its blood, though it would not be unreasonable to ascribe this 

 to an extra bile flow due to the fatty nature of the diet. In the second 

 series of experiments (B) in which the blood was taken after the digestive 

 process was completed, the percentages found were of much the same order 

 of magnitude as in the first series, with the exception of Experiment XVII. 

 It will be noticed, however, that the percentage in the blood of the retriever 

 dog fed on brain was slightly less than that in the blood of the dogs fed on 

 meal, and bread and egg-white respectively. These animals were, however, 

 very different in weight and were of different varieties. 



