132 Origin and Destiny of Cholesterol in the Animal Organism. 



Table III. 





Weiglit of 



eggs 

 in grammes. 



"Weight of 

 unsaponifiable 



matter 

 in grammes. 



"Weight of 

 cholesterol 

 in grammes. 



Percentage 

 of 



cholesterol. 



6 eggs analysed together 



8 eggs analysed separately 



6 eggs analysed separately ; same 

 as above, eliminating 1 and 5 



359 -00 

 457 -55 

 337 "52 



2 -4025 

 2 -9488 

 2 -2199 



1 -7578 

 1 -7509 

 1 -3910 



-4896 

 -3827 

 -4121 



Table IV. 





Weight of 



eggs in 

 granmies. 



Weight of 

 chicks in 

 grammes. 



Weight of 

 unsaponi- 

 fiable 

 matter in 

 grammes. 



Weight of 

 cholesterol 

 in 



grammes. 



Percentage 

 referred 



to weight 

 of egg. 



Cholesterol 

 referred 

 to weight 

 of chick. 



6 chicks analysed together . . . 

 8 chicks analysed separately 

 6 chicks analysed separately ; 



same as above, eliminating 



11 and 15 



340 -2 

 462 -84 

 342 -73 



302 

 411 -1 

 301 -91 



1 -7805 



2 -9108 

 1 -9878 



1 -5914 

 1 -4683 

 1 -1952 



-4677 

 -3172 

 0-3487 



-5270 

 3693 

 -3958 



accumulated. A comparison of the figures again shows that no gain in 

 cholesterol takes place during the incubation of the chick. Whether the- 

 cholesterol of the egg remains unchanged, or whether some loss occurs,, 

 cannot be definitely decided. 



Conclusions. 



In the differentiation of the ovum into the complex aggregates of cells- 

 constituting the chick, no formation of cholesterol takes place. This is in 

 accordance with our view that cholesterol is not synthesised in the organism. 



This work has been carried out with the help of a grant which was made- 

 to us by the Government Grant Committee of the Eoyal Society, for which 

 we take this opportunity of expressing our thanks. 



