The Discovery of a Remedy for Malignant Jaundice, etc. 349 

 Results of Treatment with Trypanblau (up to June 17, 1909). 







Control dogs. 



Dog. 



Treated dogs. 



(Inoculated at the same time as 

 the treated dogs.) 



1 



2 

 3 

 4 

 5 

 6 

 7 

 8 

 9 

 10 



11 



Kept under observation 90 days 



83 „ 



69 „ 



65 „ 



42 , 



43 .„ 



52 „ 



Died of relapse after 13 „ 



„ . is „ .-: 



Treated when moribund, the dog died three 

 hours later, but the drug obviously affected the 

 parasites 



Treated 24 hours after inoculation {i.e. before 

 the parasites had appeared), dog alive and well 

 after 65 days ; it never showed parasites 



Control died after 7 days. 



7 

 9 

 8 

 36 

 8 

 7 

 7 

 7 



Results of Treatment with Trypanrot. 



Dog. 



Treated dogs. 



Control dogs. 



12 

 13 



Alive and well after 111 days Control dog died after 9 days. 



Treated in an advanced stage of the disease, „ „ 7 „ 



the dog died 20 days after inoculation, but 



no parasites could be found in the blood, j 



The dog apparently died from the after 



effects of piroplasmosis 



The above table speaks for itself, it scarcely requires any comment. "We 

 very much regret that we have lost four of our treated dogs from inter-current 

 disease. Two of these dogs died of distemper (42 and 43 days respectively 

 after inoculation), one died of distemper and mange combined (69 days after 

 inoculation), and one died of severe generalised mange due to Demodcx 

 follictdorum (52 days after inoculation). Dog 13 was treated in an advanced 

 stage of the disease, but its life was prolonged ; it is worthy of note that no 

 parasites could be found in the animal at autopsy. Dog 10 was treated only 

 three hours before death ; the drug markedly affected the parasites, but it 

 was too late to save the dog's life. In only two cases did we see a relapse 

 follow five days after apparently successful treatment ; this was in two very 

 small and poorly developed puppies. The remaining dogs are alive and well 

 to-day and show no parasites microscopically in their blood. 



As previously stated, the drugs exert a direct effect upon the parasites. 

 The percentage of infected corpuscles is decreased, the pyriform parasites 

 disappear, rounded and degenerated parasites are seen for a time, and, after 



