1 909.] Experimental Treatment of Trypanosomiasis. 357" 



lactate 17 per cent., so they are both much weaker in antimony than the 

 tartrates which we have used. By the addition of a small quantity of lactic- 

 acid we were able to get a 1 per cent, solution of both salts, and in this- 

 strength the solutions were not very irritating, but neither with rats nor with 

 larger animals are they as effective as the tartrates or the metal. 



The following table shows the results obtained with sodium antimony 

 lactate 1 per cent. 



Average duration of untreated disease 6'9 days : — 



Eats of 150 to 

 200 grammes 

 weight. 



Number of doses, 

 and quantity. 



Recurrences. 



Lived. 



Remarks. 



1 



2 of 4 minims 







9 days 



Died from enteritis. 



2 



4 of 4 „ 







20 „ 



Died from retained foetus. 



3 



4 of 4 „ 



1! 



37 „ 





4. 



5 of 4 „ 



1 



46 „ 





5 



6 of 4 „ 



2 



100 „ 



(No trypanosomes found 



6 



4 of 5 „ 







74 „ 



in any of these rats after 



7 



5 of 5 „ 



1 



48 „ 



death.) 



The following table shows the results obtained with antimony sodium calcium 

 lactate 1 percent. 

 Average duration of untreated disease 6 - 9 days : — 



Rats of 150 to 

 200 grammes 

 weight. 



Number of 

 doses, and 

 quantity. 



Recur- 

 rences. 



Lived. 



Remarks. 



1 



3 of 4 minims 



1 



83 days 



No trypanosomes found post mortem. 



2 



4 of 4 ,, 







25 „ 



Living trypanosomes found post mortem. 



3 



5 of 4 „ 



2 



63 „ 



No trypanosomes found post mortem. 



4 



6 of 4 „ 



2 



45 „ 



5» »» )) 



5 



5 of 5 „ 



2 



64 „ 



j) j) j) 



6 



6 of 5 „ 



2 



68 „ 



>» >> >> 



7 



8 of 5 „ 



2 



57 „ 



» >> >> 



8 



4 of 7 „ 







131 „ 



j> )» j> 



On dogs the effect was very much less marked than on rats, and ani 

 effective dose became inconveniently large. 



The following experiments show the relatively greater time taken for these 

 salts to act, as compared with the sodium or lithium antimonyl tartrates, 

 which drive all the trypanosomes from the peripheral blood in about an hour 

 after the dose. 



A Surra rat was taken on the fourth day, when the trypanosomes are- 

 numerous in the blood, and 5 minims of a 1 per cent, solution of sodium 

 antimony lactate were injected. 



2 D 2 



