358 Mr. Plimmerand Capt. Fry. Further Results of [June 28, 



Blood was taken and showed the following : 



\ hour after injection. . . Trypanosomes affected by the drug : are extremely 



active, and show a tendency to swell. 



1 „ „ ... Very few normal trypanosomes to be seen : nearly 



all are swollen and spherical in shape 

 (= " battledores "). Still large numbers. 

 \\ hours „ ... Much smaller number of trypanosomes to be seen : 



a few " battledores " : a few motionless ones, 

 and one or two normal forms. 



2 „ „ ..." Battledores " have all disappeared : one or two 



slowly moving normal forms seen. 

 2 J „ „ ... Ditto. 



2>\ „ „ ... No trypanosomes found. 



A similar experiment made with a rat treated with antimony sodium 

 calcium lactate yielded practically the same result. Further experiments 

 made with these drugs in vitro will be mentioned later. 



Experimen made with Antimony {Metal in state of finest Division) suspended 



in various Oily Media. 

 Since the curative results following treatment with the metal antimony* 

 suspended in Colonel Lambkin's medium seemed promising, many trials have 

 been made with the metal suspended in other oily media, such as olive oil, 

 cod liver oil, lanolin, egg-yolk, etc., in order, if possible, to obviate, or at any 

 rate reduce, the extremely irritating properties of the metal, which seriously 

 interfere with its practical use. 



In olive oil a 5 per cent, suspension was used : with one dose of 3 minims 

 Surra rats lived for 15 days, and died with living trypanosomes in their 

 blood. Seventeen Surra rats were given one dose of 5 minims on the fourth 

 ,day of the disease, and they lived from 41 to 133 days : in these there were 

 no recurrences, nor were trypanosomes found after death, and sub-inoculations 

 were in every case negative. Six Surra rats were treated with the same 

 dose in order to observe the time taken for the complete disappearance of 

 the trypanosomes from the blood. 



Blood was taken and showed the following : 



| hour after injection... Trypanosomes very active. 



1 „ „ ... As numerous : show "evidences of swelling. 



1£ hours „ ... Still numerous : nearly all swollen : some " battle- 



dores." 



2 „ „ ... Very few forms found : all " battledores." 

 2£ „ „ ... No trypanosomes seen. 



* ' Eoy. Soc. Proc.,' B, vol. 80, p. 483. 



