1909.] 



The Functions of the Pituitary Body. 



461 



urine was increased from about 1 litre to \\ to 2 litres per diem ; in the 

 second from 1100 to 1300 c.c. ; and in the third case, which was already 

 diabetic, the increase was from 16 to 21 litres. J. Azam (1908) observed a 

 marked diuresis as one of the effects of administration of - 3 to 0"4 gramme 

 ox pituitary in cases o'f infectious fevers. 



The accompanying chart (fig. 6) of a feeding experiment upon rats may 

 also be here given in illustration of the diuretic effect of pituitary feeding. 



f 90 



2 80 



o 



a. 



-a jo 



to 60 

 o 



CL 

 O 



6 40 

 c 



«? 30 



Dates 







i—*. — 



















N 



\ 



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vv 



\ \ 

 \ ' 















// 

 // 





\ 

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// 





















































14 



May 



28 



I 



June 



15' 



29 



6 



July 



Fig. 6. — Chart of Urine Secretion of two full-grown Male Eats, A 4 and B 4 , fed on bread 

 and milk, to which in the case of A 4 a small addition of dry sheep's pituitary was 

 made on and after June 1, while B 4 was given as a control a similar addition of dry 

 testicular substance. 



The chart shows the amount of urine in cubic centimetres per kilogramme 

 and per diem secreted prior to and during the administration (along with 

 the ordinary bread and milk food) of a small amount of sheep's pituitary. 

 In this case the whole gland was used, a little of the dry powder, which had 

 been kept for several years, being added to the food. Two large male rats 

 were chosen of about the same weight (250 grammes), one for use as a 

 control. To the food of this one an equal amount of dry testicular substance 

 was added during the time that the other one was receiving pituitary sub- 

 stance. A preliminary observation was first made, extending over rather more 

 than two weeks, no addition being made to the ordinary food. As a result 

 of this it was found that one of the two rats secreted rather less urine per 

 kilogramme body-weight than the other. This one (A 4 ) was selected for the 

 pituitary addition, and the other (B 4 ) for the control. During the first week 

 of pituitary feeding the curve of the urine secretion of A 4 is approaching 

 that of B 4 ; during the second week it crosses it, and in the subsequent weeks 

 it maintains a higher position, so that in place of secreting about 25 per 

 cent, less urine than B 4 , as was the case before the feeding with pituitary 



