462 



Prof. E. A. Schafer. 



[July 22, 



began, it now secretes about 25 per cent. more. The same fact is illustrated 

 towards the termination of the experiment which is illustrated by the chart 

 given in fig. 2. 



Grafting Experiments. 



The effects upon the secretion of urine of grafting pituitary have already 

 been referred to in connection with growth, but it may be of interest to 

 record some of the results on urine-secretion which have been yielded in our 

 attempts to effect the implantation. 



A cat, which was passing, prior to the operation, 207 c.c. of urine per 

 diem (average of 15 days), was found to pass during the 15 days succeeding 

 the implantation of the pituitary of another cat into its peritoneal cavity 

 an average of 276 c.c, the greatest increase being during the first week after 

 the operation. In another cat the average amounts were 180 c.c. (before) 

 and 233 c.c. (after). In a monkey the amounts recorded were 202 c.c. and 

 255 c.c. respectively — for a daily average during 16 days before and after 

 the implantation. Of two rabbits operated upon in this way, the effect pro- 

 duced in one was hardly noticeable, but in the other the amount of urine rose 



1-70 

 160 



150 



£ 



a> 140 

 ■o 

 L. 



g_I30 



T3 



5 120 



hi) 



o 



— no 



S- 



<v 



Q.IOO 



d 

 d 



.S 90 



| 80 

 70 

 60 

 50 



DaCes 5 9 13 II 21 25 29 i 8 

 March April 



Fig. 7. — Chart of Urine Secretion of two groups of full-grown Eats (three in each group) : 

 Group A 1 with pituitary implantation into muscles of back ; Group B, controls. 

 The implantations were made on March 9. 



