1911.] The Action of Animal Extracts on Milk Secretion. 21 



was registered, but within less than a minute of the injection the f 

 and was, in fact, at first so rapid that two or 

 three drops fell at the side and escaped 

 registration. The galactagogue action in this 

 case lasted about ten minutes. A second dose 

 proved ineffective. 



We have further investigated the action of a 

 number of drugs which from their influence on 

 other glands might have been expected to 

 influence the secretion of the mammary gland ; 

 but with negative results. Amongst these may 

 be mentioned pilocarpine, eserine, and nicotine. 

 A dose of pilocarpine capable of producing 

 intense salivation and lacrimation has no per- 

 ceptible influence on milk secretion. Secretine 

 also gives a negative result. Nor have we so 

 far succeeded in obtaining any positive result 

 from the electrical excitation of the nerves to 

 the glands. Our experiments in this direction 

 have not been sufficiently numerous for us to 

 state definitely that no effect is under any 

 circumstances so obtainable, but hitherto neither 

 by reflex nor by direct stimulation have we 

 been able to cause a flow of milk from the 

 nipple. The work in this and in some other 

 directions is, however, still in progress, and the 

 results will be given in a later communication. 



Within the last few days, and since the 

 completion of our joint work upon this subject,* 

 there has come into our hands the number of 

 the •' Proceedings of the Society of Experimental 

 Biology of New York^' which describes the 

 communications made to that Society at its 

 meeting on December 21, 1910. Amongst these 

 communications are two by Drs. Isaac Ott and 

 J. C. Scott, which deal with the galactagogue 

 action not only of " infundibulin " but also 

 of other animal extracts. These authors 

 have used the goat as the subject of their 



* The experiments are being' continued by Dr. Mackenzie alone. 



