156 Messrs. H. S. Stannus and W. Yorke. Pathogenic [May 3, 



(1) An hypertrophy of the thyroid gland of goats can he induced by 

 infecting the water supply with the faeces of sufferers from goitre. It is 

 at present impossible to state whether this hypertrophy is due to the action 

 of the infecting agent of goitre, or only to the organic impurity of the water 

 thus contaminated. 



(2) Earthworms do not appear to be concerned in the spread of goitre. 



(3) The microscopical appearances described are the earliest stages in the 

 formation of parenchymatous goitre. 



The microphotographs (Plate 1*) illustrate the appearances seen under a 

 magnification of 100 diameters. Fig. 1 shows the normal appearance of 

 the thyroid gland of a goat. Fig. 2 shows the artificially produced parenchy- 

 matous goitre. 



The Pathogenic Agent in a Case of Human Trypanosomiasis in 

 Nyasaland. 

 By Hugh S. Stannus and Warrington Yorke. 



(Communicated by Major R. Eoss, F.R.S. Received May 3, — Read June 1, 

 1911.) 



[Plate 2.] 



Up to the time of writing, nearly 40 cases of trypanosomiasis have been 

 discovered in Nyasaland, whereas Glossina palpalis, notwithstanding much 

 careful searching, has not, as yet, been found in the Protectorate. In view 

 of this fact and also of the observation that the trypanosome derived from 

 a case of Sleeping Sickness contracted in North-East Rhodesia has been 

 shown to present certain peculiarities both morphological* and also regarding 

 its pathogenicityt in experimental animals, it appeared to us desirable to 

 examine in some detail the parasite derived from a case of human 

 trypanosomiasis infected in Nyasaland. The trypanosome to which this 

 paper refers was obtained from the blood of Mr. R., Case 12 in the Nyasa- 

 land Sleeping Sickness Diary. 



The following is a short summary of the history of this case : — Patient 



* Stephens and Fantham, " On the Peculiar Morphology of a Trypanosome from a 

 Case of Sleeping Sickness and the Possibility of its being a New Species (T. rhodesiense)," 

 ' Eoy. Soc. Proc.,' 1910, B, vol. 83, p. 28. 



t Yorke, W., "On the Pathogenicity of a Trypanosome from a Case of Sleeping 

 Sickness Contracted in Ehodesia," ' Annals of Tropical Medicine,' 1910, vol. 4. 



