191 



The Viability of Human Carcinoma in Animals. 

 By Major C. L. Williams, M.D, I.M.S. (ret.). 



(Communicated by Prof. C. S. Sherrington, F.R.S. Received June 14, — 

 Read June 29, 1911.) 



(From the Cancer Research Laboratory, University of Liverpool — Mrs. Sutton Timmis 

 Memorial.) 



The object of the present research is to determine the cell changes 

 occurring in portions of human carcinoma implanted into animals, and more 

 particularly to ascertain if such implanted tissues are capable of surviving for 

 a time, and if so, the manner in which they succumb. 



Implantation of human carcinoma into animals has been made by 

 numerous observers, and the failure of such implantations to produce 

 tumours is now an ascertained fact. Among the earliest experiments are 

 those of Ballance and Shattock,* the objective of which was to determine 

 if human carcinoma was transferable from man to animals ; in these observa- 

 tions the immediate effect of implantation upon the cells of the growth was 

 not determined. Yon Langenbeck,f Jurgens,f Dagonet and Mauclaire,j and 

 Gaylord§ produced in animals, by inoculation of carcinoma, tumours which, 

 however, differed in structure from the original. Lewin|| succeeded in 

 obtaining inoculable granulomata in dogs by implantation of a human 

 ovarian carcinoma, and also in rats by inoculation of a carcinoma of the 

 cervix of the human uterus ; ( this author made numerous attempts to obtain 

 inoculable tissues by implantation of human carcinoma, but only the above 

 two were successful. 



The effect of implantation of mouse carcinoma and sarcoma into rats has 

 been studied by Ehrlich,1T who found that during the first 8 — 10 days 

 after inoculation the rate of growth was scarcely less than before implantation ; 



* " A Note on an Experimental Investigation into the Pathology of Cancer," ' Roy. 

 Soc. Proc.,' 1890, vol. 48, p. 392 ; 'Brit. Med. Journ.,' 1891, 1, p. 565. 

 t Quoted by Lewin, loc. cit. 



% "Versuche iiber die Ubertragbarkeit des menschlichen Caicinoms auf die Ratte," 

 ' Archives de Medecine Experimental, 1 1904, No. 5, September. 



§ " liber die Bedeutung der Plimmerscher (bezw. Sjobringsclien) Korperchen und die 

 durch menschliches Material erzeugtes Krebswucherung bei Tieren,"' ' Zeitschr. f. 

 Krebsforschung,' 1903, vol. 1, p. 93. 



|| " Uber Versuche, durch Ubertragung von menschlichen Krebsmaterial verimpfbare 

 Geschwiilste bei Tieren zu erzeugen." 



IT 'Beitrage zur experimentellen Pathologie und Chemotherapie,' Leipzig, 1909, 

 p. 135. 



