PROCEEDINGS OF 



THE BOYAL SOCIETY. 



Suction B. — Biological Scijencus. 



By J. C. MoTTRAM, M.B. (Lend.), and Sidney Kuss, D.Sc. (Lend.), Cancer 

 Eesearch Laboratories, Middlesex Hospital. 



(Communicated by Prof. H. G. Plimmer, F.E.S. Received November 9, 1916.) 



[Plates 1 and 2.] 



CONTENTS. 



Part I. Page. 



Conditions of Susceptibility and Immunity 2 



1. The Condition of Susceptibility 2 



2. The Condition of Immunity 4 



(a) General 4 



(b) Production of Immunity 4 



(c) Condition of Tissues 7 



3. The Effect of Experimental Alteration of Susceptible and Immune Animals 



upon Subsequent Inoculation 10 



(a) Splenectomy '. ; 10 



(6) Large Inoculation •. 10 



(c) Exposure to X-rays 11 



4. The Effect of Experimental Alteration of the Sarcoma Cell before Inocula- 



tion into Susceptible and Immune Animals 13 



(a) Mixture of Sarcoma Cells with Spleen and Liver, etc 13 



Part 11. 



Microscopic Observations upon Grafts and Tumours 16 



1. The Study of the Graft in Susceptible Animals 17 



2. The Study of the Graft in Immune Animals 20 



3. The Study of the Graft in Animals vs^hich have been Experimentally Altered 



before Inoculation 22 



4. The Study of the Graft in Animals Inoculated with Altered Sarcoma Cells 23 



5. The Study of Regressing and Oscillating Tumours 24 



6. Comparison of Results 25 



Part III. 



General Discussion and Conclusions 28 



VOL. XC. — B. B 



