144 Intravenous Injections of Diamino-Acridine Sulphate. 



intravenous injections of diamino-metliyl-aciidinium chloride have shown 

 that, after a dose of 0"15-0'3 grm. (in the form of a 1 : 1000 solution in 

 physiological saline), fully a third of this amount can be accounted for in the 

 urine passed during the subsequent two days.* 



Thus it is possible that these or allied substances may prove of value in 

 infections of the kidney and the biliary passages. 



REFERENCES. 



Bechhold and Ehrlicli, 'Zeitschr. Physiol. Chemie,' vol. 47, p. 173 (1906) ; ibid., vol. 52, 

 p. 77 (1907). 



Benda, ' Ber. Deutsch. Chem. Ges.,' vol. 45, p. 1787 (1912). 



Browning and Gilmour, ' Journ. Path, and Bact.,' vol. 18, p. 144 (1913). 



Browning, Gulbransen, Kennaway and Thornton, ' Brit. Med. Journ.,' January 20 



and July 21, 1917. 

 Chick, 'Journal of Hygiene, vol. 12, p. 414 (1912). 

 Morgenroth and Levy, ' Berlin. Klin. Woch.,' 1911, Nos. 33 and 44. 

 Wright and Windsor, 'Journal of Hygiene,' vol. 11, p. 385 (1902). 



* We are indebted to Captain T. F. Cotton, C.A.M.C., for the clinical material and 

 to Dr. S. Euss for the estimations from absorption spectra. It is important that 

 specimens of this substance to be employed for internal administration should be free 

 from admixture with traces of poisonous metals. 



