Teeth of the Guinea-pig, produced hy a Scorbutic Diet. 509 



Table. 



JNo. 



_ 



iJTiratioii 



01 



expenment. 



Initial 

 ■sreight. 



Final 

 weight. 



1 ostmortein remarks. 



_ ... 

 Condition 



or 



reecn. 





days. 



gi-m. 



grm. 







372 



7 



362 



372 





Normal. 



373 



7 



385 



884 





Blood vessels 













slightly dilated. 



366 



10 



254 



323 



Slight haemorrhages in femoral muscles 



+ + 











and along lower ribs. Jlverything else 













normal. 





367 



10 



285 



370 





Normal. 



368 



12 



258 



327 



Slight haemorrhages in femoral muscles 



+ + 











and along lower ribs. Slight " beading 













at costochondral junctions. 





369 



12 



246 



306 



Slight haemorrhages in femoral muscles ; 



+ 











bones somewhat brittle. Slight " bead- 













ing " of costochondral junctions. 





370 



17 



241 



270 



Very marked haemorrhages in femoral 



+ 











muscles. Enlarged and haemorrhagic 













costochondral junctions. Shafts of 













femur and tibia brittle near epiphyseal 













junctions. 





371 



17 



265 



254 





+ + + 



This was possible with guinea-pigs, as these animals can maintain themselves 

 when removed from their mother immediately after birth. The following 

 protocols describe three representative cases : — 



1. G-uinea-pig No. 316, born on May 30, 1918, was put immediately on a 

 diet of oats, bran, and autoclaved milk. It weighed 89 gram, at the time of 

 its birth. On June 14, 1918, it reached its maximum weight of 135 gram. 

 From that day it commenced losing in weight and died on June 24, 1918, 

 weighing 113 gram. At the post-mortem examination it was found that the 

 intestinal walls appeared to be hsemorrhagiq, although no haemorrhages were 

 found elsewhere. The bones of the fore and hind limbs were very soft. 

 There was decided "beading" at the costochondral junctions. The ribs of 

 this and the following animals were kindly examined for us, histologically, by 

 Miss F. M. Tozer, who found fractures and disorganised junctions of the 

 cartilage and bone. The structure of the teeth of this animal was modified 

 to a marked extent and was assessed by us to be + -H . 



Guinea-pig No. 313, born May 30, 1918, weighing 97 gram., was put on 

 scorbutic diet of oats, bran, and autoclaved milk immediately after birth. It 

 received also occasional small doses of orange juice, enough to delay the fatal 

 termination but not adequate to prevent scurvy. After about 15 days the 

 animal displayed definite systems of scurvy. It was kept in this condition until 

 July 23, 1918, when it died, weighing only 128 gram., which was far below 



