Action of Sodium Glycocliolate. 99 



Table XIII. — A. Sensitive Suspension. 



Histamine. 



Grlvcochoiate. 



1 in 



1 in 100. 



1 in 200. 



| 



j 1 in 300. 



1 



1 m 400. 



1 in 500. 



1 in 600. 



1 in 1000. 



500 



5 sees. 



5 sees. 



3 sees. 



8 sees. 



10 sees. 



25 sees. 



40 sees. 



1,000 



7 „ 



7 ,, 



5 „ 



15 , s 



20 ., 



35 „ 



1| mins. 



2,000 



8 „ 



10 „ 



10 „ 



20 „ 



25 „ 



30 „ 



2 „ 



5,000 



45 mius. 



15 mins. 



! 30 „ 



30 „ 



28 „ 



20 „ 





8,000 



50 „ 



18 „ 



S 45 „ 



45 ,, 



30 „ 



25 „ 



1 min. 



10,000 



56 „ 



24 „ 



2% mins. 



2 mins. 



1 min. 



30 „ 



50 sees. 



Table XIV. — B. Insensitive Suspension. 



Histamine. 



G-lycocholate. 



1 in 



1 in 100. 



1 in 200. 



1 in 300. 



1 in 400. 



1 in 500. 



1 in 600. 



1 in 1000. 



500 



5 sees. 



5 sees. 



5 sees. 



8 sees. 



10 sees. 



15 sees. 



40 sees. 



1,000 





7 „ 



10 „ 



15 „ 



18 „ 



28 „ 



H mins. 



2,000 



1 : 



10 „ 



15 „ 



20 „ 



25 „ 



30 „ 



2 „ 



5,000 



85 mins. 



40 mins. 



1 min. 



30 „ 



25 „ 



23 „ 



ii .„ 



8,000 



90 „ 



42 „ 



5 mins. 



45 „ 



30 „ 



25 „ 



1 min. 



10,000 



105 „ 



45 „ 



7 „ 



2 mins. 



1 min. 



30 „ 



50 sees. 



From these somewhat complicated Tables very little new is to be learnt, 

 except that the occurrences which take place when the action of glycocliolate 

 of sodium is accelerated by histamine are exceedingly complex. Several 

 points may, however, be noted : — 



(1) If these times be plotted on graph paper, a series of curves of defiuite 

 character will be obtained. The character of the curves, however, does not 

 suggest any generalisation. 



(2) The difference between the sensitive and the insensitive suspension may 

 be seen in columns 1, 2 and 3 of the respective Tables. At the other dilutions 

 these differences diminish. This is confirmatory of the observations made 

 with serum albumin. 



.(3) From an inspection of columns 1 and 2, it appears that there is a very 

 great disproportion between the effect produced by a 1 in 2000 histamine 

 solution and a 1 in 5000 solution. This susKests that the occurrences met 

 with when 1 in 500 to 1 in 2000 histamine is used are different in kind from 

 those met with when more dilute histamine solutions are used, whereas the 

 difference between the activity of the solutions to which the other columns 

 relate is one of degree only. This is very probable, in the light of other con- 

 siderations, and will be commented on later. 



