On the Interstitial Cells in Testicle of Guinea- Pig : 141 



augmented relative number, and consequently with a highly diminished 

 absolute number, of interstitial cells may suffice for a normal masculinisation. 



B. On comparing testicular fragments supplied by blood in different ways 

 (a fragment from the upper and a fragment from the under pole of the 

 testicle) one finds that the fragment which seems to be better supplied by 

 blood shows more pronounced tendency to hypertrophy of interstitial cells. 



C. Enormous hypertrophy of interstitial cells may take place in an upper 

 testicular fragment even when the other testicle is present in the body. 



D. Marked hypertrophy of interstitial cells may take place when we 

 transform both testicles into upper " fragments," by sectioning the testicle 

 near the under pole and by so cutting away only a very small quantity of 

 testicular mass. 



In view of all these experiments it seems clear that hypertrophy of the 

 interstitial cells, as observed in different experimental conditions, has nothing 

 to do with the internally secretory function of the testicle in its relation to 

 the organism as a whole. This hypertrophy is caused by local conditions, and 

 is not brought about in response to general compensatory requirements. 



BEFEEENCES. 



(1) Lipschutz, ' Die Pubertatsdriise und ihre Wirkungen,' Berne, 1919. See 



Chapter IV. 



(2) Bouin et Ancel, " Rech. sur le r61e de la gl. interstit. du testic. Hypertrophic com- 



pensatr. experim.," ' C. E. Acad. Sc.,' vol. 137, p. 1289 (1903) ; Ancel et Bouin, 

 " La gl. interst. a seule, dana le test., une action gener. sur 1'organisme," ' C. B. 

 Acad. Sc.,' vol. 138 (1904). 



(3) Ancel et Bouin, " De la gl. interst. du testic. des mammif," ' Jl. de physiol. et pathol. 



gener.,' vol. 6 (1904). 



(4) Sand, 'Experim. Studier over K0nskarakterer hos Pattedyr.,' Copenhagen, 1918. 



(5) Eibbert, " Ueber die kompensator. Hypertr. der Geschlechtsdr.," ' Virckow's 



Archiv,' vol. 120 (1890). 



(6) Lipschutz et Ottow, " Sur les consequences de la castr. partielle," 'C. E. Soc. Biol.,' 



vol. 83 (1920). 



(7) Lipschutz, ' Die Pubertatsdr., etc' See p. 135. 



(8) Lipschutz et Ottow, loc. cit., sub. 6. 



(8a) Pezard, " Castr. aliment, chez les coqs soumis au regime carne exclusif ," ' C. E. 

 Acad. Sc.,' vol. 169 (1919). 



(9) Lipschutz, Ottow et Wagner, "Nouvelles observat. sur la castra. part.," 'C. E. Soc. 



Biol.,' vol. 85 (1921). 



(10) Lipschutz, Ottow et "Wagner, ' Sur ie ralentissement de la masculinisation dans la 



castr. part.' (In print.) 



(11) Poll, " Zwischenzellengeschwiilste d. Hodens bei Vogelmischlingen," ' Beitr. z. 



patholog. Anat.,' vol. 67 (1920). 

 (11a) Lipschutz, Ottow et "Wagner, "Sur des modific. histolog. subies par des restes du pole 

 inffr. du testic. dans la castr. part.," ( C. E. Soc. Biol.,' vol. 85 (1921) ; Lipschutz, 

 Ottow et Wagner, " Sur des modific. histolog. subies par des restes du p61e superieur 

 du testic. dans la castr. part.," ' C. E. Soc. Biol.,' vol. 85 (1921). 



