Antiseptic Action and Chemical Constitution. 329 



LITERATURE. 



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Allen, B., 'Biol. Bull.,' vol. 32 (1917). 



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 Dixon, ' J. Physiol.' (1904). 



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(1916) and vol. 42 (1917) ; ' J. Pharm. and Exp. Ther.' (1917). 

 Swingle, ' J. Exp. Zool.,' vol. 34 (1921). 



Relationships betiveen Antiseptic Action and Chemical Constitution 

 with special reference to Compounds of the Pyridine, Quinoline, 

 Acridine and Phenelzine Series* 

 By C. H. Browning, J. B. Cohen, F.B.S., 11. Gaunt, and Pi. Gulbeansen. ' 



(Eeceived October 25, 1921.) 



(From the Organic Chemistry Laboratory, University of Leeds, the Bland-Sutton 

 Institute of Pathology, Middlesex Hospital, and the Pathological Department of 

 the University and Western Infirmary, Glasgow.) 



Biological Section. 

 In the course of investigations on the antiseptic properties of certain 

 basic benzene derivatives, it was shown that the methochloride of 

 diaminoacridine was very highly antiseptic, and that, unlike other powerful 

 antiseptics then known, its antibacterial activity was not reduced by the 

 presence of blood serum (Browning, Gilmour, Gulbransen, Kennaway and 

 Thornton, 2, 7). Diaminoacridine methochloride had been prepared by 



* The work reported in this communication was done with the support of the Medical 

 Research Council. 



