Antiseptic Action and Chemical Constitution. 351 



benzene was decanted from the phenochloride, which separated, and the 

 latter boiled with a little more cone, hydrochloric acid, cooled, and the 

 crystalline product filtered, washed with cone, hydrochloric acid, and finally 

 with ether. 



[44.] 2.7 '.Diaminoacridine Chloroacetate. — About 1 grm. of diacetyl 

 diaminoacridine was dissolved in about 50 c.c. of nitrobenzene and heated in 

 a metal bath to 140°-150°. An equivalent amount of chloracetic acid was 

 added and maintained at 140°-150° for about 10 minutes. On cooling, 

 yellow crystals separated, which were filtered and washed with ether. The 

 substance was readily soluble in water. On analysis, 



04485 grm. gave 0"055 grm. AgCl ; CI = 9 per cent. Calculated for 

 Ci9H 17 N 3 4 Cl ; CI = 9-05 per cent. 



On boiling the diacetyl derivative with cone, hydrochloric acid, red 

 crystals were obtained, which were purified by dissolving in water and 

 reprecipitating with cone, hydrochloric acid. 



On analysis : 



0141 grm. gave 0127 grm. AgCl ; CI = 22-2 per cent. Calculated for 

 * C 16 H 18 N 3 02Cl8 ; CI = 20-9 per cent. 



OH CH 



cHs-co-hJ^J^J^Ixh-coch, h^vJ^Jnh,. 



N N 

 COOHCH 2 CI COOHCHo CI 



On addition of ammonia it was converted into the betaine 



CH 



N 



H,C<(^>0 

 CO 



[46.] 2.7 .Diaminoacridine Chloracetanilide was prepared by adding an 

 equivalent of chloracetanilide to diacetyl diaminoacridine in nitrobenzene 

 (1 grm. of the diacetyl derivative in 50° c.c. of nitrobenzene), heated to 

 140°-150° and maintained for 5 to 10 minutes. On cooling, an amorphous 

 brown precipitate separated, which was filtered, washed with ether, and 

 boiled with cone, hydrochloric acid. Brown crystals were obtained and 

 were purified by dissolving them in water, and reprecipitating with cone, 

 hydrochloric acid. 



