Antiseptic Action and Chemical Constitution. 357 



boiling alcoholic solution of picric acid. The picrate which crystallised was 

 filtered and re-crystallised from boiling aniline. To the picrate suspended in 

 alcohol, caustic soda was added and warmed on the water-bath until the 

 solution was deep yellow, and then diluted. The precipitated base was 

 filtered, washed with water, dried and re-crystallised from benzene (m.p. 185°). 

 [65.] 2.7. Diamino-9. phenyl acridine carboxylic ester. — 



/\ 



lJc!OOC 3 H 3 

 I 



The substance was prepared by heating with ammonia in sealed tubes 

 according to the method of Meyer and Oppelt.* The product was boiled 

 with alcohol to remove impurities and the residue suspended in alcohol and 

 hydrogen chloride passed in. The alcohol was removed, the hydrochloride 

 dissolved in water and precipitated with salt, redissolved and again salted 

 out. The product is an orange amorphous powder. 



[66.] 2.7 ' .Tetramethyldiamino-9.phenylacricline carboxylic ester. 



COOC 2 H 6 



(CH 3 ) 2 K l x/ ! v/ l x/ !N(OH3) 2 

 N 



One molecular proportion of phthalic anhydride was heated with three of 

 acetic anhydride and two of m-aminodimethylaniline for 2-3 hours at 

 140°-150°. The acetic acid was then distilled off and the residue boiled with 

 fifteen to twenty parts of 20 per cent, hydrochloric acid for J hour. From 

 the deep red solution the base was precipitated by ammonia, filtered and dried 

 in vacuo. It was suspended in ten times its weight of absolute alcohol, 

 heated an hour with reflux on the water-bath whilst dry hydrogen chloride 

 was passed in. The alcohol was removed, the residue dissolved in hot water, 

 filtered and the filtrate salted out. The precipitate was filtered, washed with 

 a little cold water and dried. 



* 'Ber.,' vol. 21, p. 3376 (1888). 



