186 Dr. J. O. W. Barratt. The Nature of the 



Fibrinogen 

 solution. 



TTiTVlTTI HfVklTlfl «P 

 _L ill '..'ill 1.) KJ H. 1 lid -rC 



\J L 1 CU tell 

 D LI Villa Let UJ. 

 Id U Ul L / . 



'fi.npr.ppTif 



CaCh- 



t n f"i nvi 



*ftr»-npv-ppn4*. 



\J IJW |JC1 LCI1U. 



NaCI 



crtl n+i fin 



'83-per-cent. 



solution 

 of potassium 



oxalate. 



Coagulation 

 time (30° C). 



C.C. 



c.c. 



C.C. 



C.C. 



C.C. 





'2 





"03 



"27 





90 minutes. 



'2 



'01 



- 03 



'26 





21 „ 



0-2 



-03 



0-03 



0-24 



— 



7 „ 



0-2 



-10 



-03 



-17 





6 „ 



0-2 



10* 



0-03 



-17 





8 



3 hours. 



0-2 







27 



03 



02 



0-01 





0-26 



0-03 



3 



0-2 



-03 





0-24 



0-03 



24 „ 



0-2 



10 





0-17 



0-03 



a* „ 



-2 



o-io* 





0-17 



-03 



2£ „ 



* Previously heated to 60° for 5 minutes. 



The effect of heat upon a peptone solution is thus exhibited : — 



Fibrinogen 



Thrombokinase 

 (5-per-cent. 



'6-per-cent. 

 CaCl 2 

 solution. 



'85-per-cent. 

 NaCl 

 solution. 



"83-per-cent. 

 solution 



Coagulation 



solution. 



solution 

 of peptone). 



of potassium 

 oxalate. 



time (30° C). 



C.C. 



c.c. 



C.C. 



C.C. 



C.C. 



/ 



0-2 





0-03 



0-27 





90 minutes. 



0-2 



01 



0-03 



-26 





12 „ 



0-2 



03 



0-03 



0-24 





15 „ 



-2 



o-io 



0-03 



0-17 





20 



0-2 



-30 



0-03 







50 



0-2 



0-01* 



0-03 



0-26 





15 „ 

 3 hours. 



0-2 







-27 



0-03 



2 



o-oi 





-26 



0-03 



2£ „ 



0-2 



-03 





0-24 



-03 



2* „ 



0-2 



o-io 





0-17 



0-03 



2h „ 



0-2 



0-30 







-03 



21- „ 



0-2 



o-oi* 





0-26 



-03 



2i „ 



* Previously heated to 60^ for 5 minutes. 



With the addition of increasing amounts of peptone in presence of 

 -calcium chloride delay of the onset of coagulation was observed, the coagula 

 being very soft. 



The Action of Viper Venom upon Circulating Blood Plasma. 



The lethal amount of the venom of Echis carinatus (administered by intra- 

 venous injection) was found by C. J. Martin to be for the rabbit about 

 half a milligramme per kilogramme of body weight ; if a large dose of viper 

 venom was injected rapidly into a vein, intravascular clotting occurred ; 

 if a relatively small dose was injected very slowly, the coagulability of the 



