328 



Prof. G. Dreyer and Dr. E. W. A. Walker. 



approximating to dosage by the surface area. But below the age of five years 

 the dosage by Young's formula falls more and more rapidly below the dose 

 calculated in relation to body surface. 



We append a table showing the doses which would be given at different 

 ages from 1 year to 21 years in a system of dosage calculated in relation to 

 blood volume and body surface, taking the weights at the different ages as 

 given in Vierodt's tables, 1893. 



Table of Dosage. 



in years. 



A yt?vii,gp weight, 



Dose in relation to 

 surf ace. 



Dose as a fraction 

 of dose for adult. 



21 







61,200 







100 



i 

 i 



20 



59,500 



98 "8 





19 



57,600 



95 7 





18 



53,900 



92 5 





17 



49,700 



86 "2 





16 



45,400 



81 4 





15 



41,200 



75 -1 



4 



14 



37,100 



70 1 





13 



33,100 



64 -7 





12 



29,000 



58 3 





11 



27,000 



55 "4 





10 



25,200 



52 "8 





9 



23,500 



50 6 



1 

 2 



8 



21,600 



47 "2 





7 



19,700 



44 -6 





6 



17.800 



41 1 





5 



15,900 



38 -1 





4 



14,000 



34 -3 



1 



3 



3 



12,500 



31 -7 





2 



11,000 



29 2 





1 



9,000 



25 -1 



■iv 



4 







3,100 



118 



1 

 1 O 



In the abovejtable the dose in relation to the surface is given as calculated 

 from the body weight, and points are indicated where the calculated dose approxi- 

 mates to a simple fraction of the adult dose. These work out extremely 

 conveniently for practical application. Thus at 15 years (approximately 

 three-quarters of the adult age of 21) the dose is f ; at 9-10 years 

 (nearly half the adult age) the dose is \ ; at 3-4 years it may be given as ±; 

 at 1 year of age it is \ ;• below that age it sinks to as little as of the adult 

 dose. 



In conclusion we would draw attention to the fact that as long ago as 

 1818 Hufeland (24) gave the dose at fifteen years as f and the dose at one 

 year as \, though he i placed the half dose at six years of age instead of at 

 nine or ten as our table makes it. Thus it appears that both he and Young 

 already recognised the necessity of giving relatively larger doses than 



