438 Mr. Hammond and Dr. Marshall. Correlation between 



Aschner and Grigoriu in a recent paper describe the effects of injecting 

 placental extract into virgin guinea-pigs. Development of the glands 

 followed, and this was succeeded by milk secretion. In the guinea-pig 

 ovulation may take place spontaneously, so that it is probable that there 

 was some gland development before the injections were made. Ovarian or 

 placental extract was found to cause hyperemia and other changes in the 

 uterus. 



Fellner has lately described marked changes in the uterus and mammary 

 glands of the rabbit after injecting extracts of corpus luteum and placenta. 

 The organs affected are said to have undergone a considerable hypertrophy, 

 but milk production could not be induced. 



Steinach has recorded experiments on guinea-pigs in which the ovaries of 

 females were transplanted into males and produced breast development. 



Doncaster in a very recent paper on sterility in cats records a case of 

 what may be regarded as milk production following upon pseudo-pregnancy. 

 Longley had previously observed that the cat, like the rabbit, normally 

 ovulates only after coition. One of Mr. Doncaster's cats after copulating 

 with a tortoise-shell male failed to become pregnant. It occurred, however, 

 to one of the present writers that since copulation had taken place it was 

 probable that corpora lutea had been formed though unaccompanied by 

 pregnancy. It seemed possible, therefore, in the light of our experiences 

 with rabbits that the cat in question might secrete milk. This was found 

 to be the case four weeks after the last copulation, and Doncaster records 

 that the secretion continued for about two weeks subsequently.] 



REFERENCES TO LITERATURE. 



Ancel and Bouin, " Sur les Homologies et la Signification des Glandes a Secretion 



interne de 1'Ovaire," ' Compt. Rend. Soc. Biol.,' vol. 67 (1909). 

 Ancel and Bouin, " Sur les Fonctions du Corps Jaune Gestatif. I. — Sur le determinisme 



de la preparation de l'uterus a la fixation de l'oeuf," 'Joum. Physiol, et Pathol. 



Generale,' vol. 12 (1910). 

 Ancel and Bouin, " Sur les Fonctions du Corps Jaune Gestatif. II. — Sur le dtterminisme 



du developpement de la glande marumaire au cours de la gestation," ' Journ. 



Physiol, et Pathol. Generale,' vol. 13 (1911). 

 Ancel and Bouin, " Sur FEvolution de la Glande Mammaire pendant la Gestation — 



Determinisme de la phase glandulaire gravidique," ' Compt. Rend. Soc. Biol ,' vol. 72 



(1912). 



Aschner and Grigoriu, " Placenta, Fotus und Keimdriise in ihrer Wirkung auf die 



Milehdriisen," 'Archiv f. Gynakol.,' vol. 94 (1911). 

 Basch, " fiber experimentelle Auslosung der Milchabsonderung," ' Monatsschr. f. Kinder- 



heilk.,' vol. 8 (1909). 

 Biedl, ' Innere Sekretion,' 2nd edition, vol. 2, Wien, 1913. 



