Drugs on the Isolated Human U tei^us. 



555 



It is clear from these experiments that adrenine has a powerful motor 

 action on the non-pregnant human uterus and Fallopian tube. The presump- 

 tion is, therefore, that the sympathetic nerve supply to it is motor in quality. 



Pituitrin decidedly stimulates the contraction of a strip of human uterus 

 as shown in Kg. 5. The effect is produced much less promptly than the 



Fig. 4.— Isolated Human Fallopian Tube from same Uterus used in fig. 3. 



Fig. 5. — Isolated Strip of Human Non-pregnant Uterus. Showing Motor Effect of 



Pituitrin. 



effect of adrenine. No such pronounced effect could be obtained on the 

 Fallopian tube belonging to the same uterus, the addition first of pituitrin 

 1 in 800 and then 1 in 400 having no effect in 15 minutes, whereas the sub- 

 sequent addition of adrenine 1 in 250,000 produced immediately powerful 

 and enduring contractions. The negative effect of pituitrin on the tube is an 

 unexpected result, seeing that the musculature of the tube is continuous with 

 that of the uterus proper. It suggests that deductions cannot be drawn from 

 experiments on the Fallopian tube alone to embrace the uterus proper. 



It has not been possible yet to secure for experiment a pregnant human 

 uterus, which is of course rarely removed. Unless, however, the human uterus 

 has a still different type of sympathetic innervation from that of all the 

 animals which have been examined, the probability is that adrenine will have 



