352 Physiology of Sugar in relation to the Blood. [June 21, 



January 2§th. 



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The gradual destruction of sugar shown by the above observations to 

 occur after the removal of blood from the system is nothing more than 

 a confirmation of what has been known for many years to take place. A 

 communication presented by me to the Royal Society in 1855, and pub- 

 lished in abstract in vol. vii. of the ' Proceedings/ contains the following 

 remarks : — " Under the changes of the decomposition of blood, normal 

 animal glucose is very readily metamorphosed. The rapidity of the me- 

 tamorphosis depends on the activity of the decomposition of the animal 

 substances present, and when the destruction of the sugar is complete, the 

 blood has assumed an acid reaction. This acid reaction of decomposing 

 blood is only observable in that which was previously pretty largely im- 

 pregnated with sugar. It appears to be owing to the formation of lactic 



acid The disappearance of sugar is more rapid where the fibrin and 



corpuscles are present than when the serum is exposed alone ; and in 

 accordance with this the blood, in the one case, undergoes decomposition 

 much sooner than in the other." 



Thus as far back as 22 years ago I directed attention to the phenomenon 

 here referred to. The phenomenon constitutes a change, the occurrence 

 of which, from the known properties of sugar, might be looked for under 

 the circumstauces. Taken by itself it implies nothing physiologically, 

 but simply stands in subordinate relation to the physiological position 

 shown by other evidence to exist. 



Sugar per 1000 parts. 

 {t '776 } ^ (mean). 

 •739. 



fa. -7061 . 7m 



\b. -694/ /UU " 



{t: S} «<> - 



{t. IS} *» - 



{t: 38} ™ - 



{I. 3?} * . 



{t. $} w „ 



[l 38} * - 



{£ 11} « „ 



fa. -9321 . 921 

 \b. -910/ yji 

 •793. 



