208 Mr. J. M. O'Connor. 



Rabbit, 1750 grm. 



Time. 



Eectal 

 temperature. 



Brain 

 temperature. 



Remarks. 



12.17 



° 



29 '4 



27 -7 



Shivering. 

 )> 



Carotid blood warmed. 



12.42 



28 -5 



28 



1.31 



29 -2 



30 -6 



Shivering. 



1.38 



29 -6 



31 



No shivering. 



2.2 



30 -2 



31 -9 



No shivering ; polypnoea. 



2.10 



30 -8 



32 



No shivering. 



Carotids no longer warmed. 



2.17 



31 -1 



30 -4 



? Shivering. 



' 2.34 



30 -8 



29 -1 



Shivering well. 

 Bath warmed. 



3.8 



31 3 



29 -3 



Shivering. 



3.29 



32 -8 



30 -5 



3.35 



34 



31 2 



No shivering. 



3.56 



37 -1 



32 -5 





On the same grounds of technical disappointments the effort to obtain the 

 important experiment in which the skin was kept above the shivering point 

 while the brain was cooled below it was abandoned. This and similar 

 experiments require essential alteration of technique. 



The importance of this experiment lies in the fact that it would effectually clear up 

 any contradictions which might exist between these results and the experiments of 

 Barbour. Barbour and Prince (13) have shown that when the brain is heated there is a 

 fall in the 2 consumption. This is, of course, explicable by the temperature of the 

 centres rising above the " shivering point." They have, however, also shown that when 

 the temperature of the brain is lowered there is an increase in 2 consumption. This 

 may constitute a discrepancy. Barbour states that when the brain is cooled there is 

 also a vaso-constriction in the skin. In this way, provided that the temperature of the 

 air is at its usual figure, the skin would become cooler and result in this secondary 

 fashion in an increase, in 2 consumption. 



The results obtained point clearly to the theory that while shivering is 

 initiated by a low brain temperature it is quantitatively controlled by the 

 skin temperature. The more accurate localisation of these two significant 

 regions does not come within the scope of this paper. The experiments of 

 Eisenschmid and Schnitzler (22) would point to the tuber cinereum as the 

 essential portion of the brain. With regard to the skin it would be too 

 great a coincidence if the temperature of the subcutaneous region into which 

 the thermometer naturally slips were accurately the governing factor. 

 Liebermeister (2), influenced by the fact that the CO2 production of fat 

 individuals was less affected by a cold bath than that of the thin, made 

 approximate calculations which led him to believe that the end organs lay 

 beneath the layer of fat on the surface of the muscles. This view is 



