212 On the Mechanism of Chemical Temperature Regulation. 



Summary. 



1. Ansesthetised cat or rabbits when not shivering consume O2 in proportion 

 to their body temperature. 



2. "When shivering more oxygen is consumed than would otherwise be 

 consumed at that body temperature. 



3. The onset of shivering is dependent on the brain temperature being 

 below a point more or less fixed in a given animal. 



4. The amount of " extra oxygen " consumed during shivering is propor- 

 tional to the extent to which the average skin temperature is below this 

 point. 



5. This point, towards which the animals regulate chemically, varies in 

 different ancesthetised animals between 30° and 39° C. 



LITERATURE. 



1. Liebermeister, ' Archiv Anat. und Physiol.,' 1860, pp. 520 and 589. 



2. Liebermeister, ' Deutsches Archiv Klin. Med.,' vol. 10, p. 89 (1872). 



3. Sanders Ezn, ' Ber. Sachs. Gesellsch. Wiss.,' 1867, p. 88. 



4. Rohrig and Zuntz, ' Pfliiger's Archiv,' vol. 4, p. 57 (1871). 



5. Senator, 'Archiv fiir Anat, und Phys.,' 1872, p. 1, and 1874. p. 18. 



6. Pfliiger and his pupils, various papers in ' Pfliiger's Archiv,' vols. 12, 13, 14, and 15 



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7. Herzog Carl Theodor, ' Zeitschrift fiir Biol.,' vol. 14, p. 79 (1878). 



8. Voit, ' Zeitschrift fur Biol.,' vol. 14, p. 57 (1878). 



9. Rubner, ' Gesetze des Energieverbrauchs bei der Ernahrung,' Berlin. 1902. 



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11. Meyer-Gottlieb, 'Die experimentelle Pharmakologie,' 2te Auflage, p. 406 (1911). 



12. Barbour, 'Archiv Exper. Path. u. Pharm.,' vol. 70, p. 1 (1914). 



13. Barbour and Prince, 'Journ. Pharmacol, and Exp. Therap.,' vol. 6, p. 1 (1914). 



14. Rmnpf, 'Pfliiger's Archiv,' vol. 33, p. 538 (1884). 



15. Krehl, ' Pathologische Physiologie,' 6te Auflage, p. 563 (1910). 



16. O'Connor, 'Journ. of Physiol.,' vol. 49, p. 113 (1915). 



17. Schultz, • Pfliiger's Archiv,' vol. 14, p. 78 (1877). 



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19. Loewy, ' Pfliiger's Archiv,' vol. 44, p. 189 (1890). 



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21. Johansson, ' Scand. Arch. f. Physiol.,' vol. 7, p. 123 (1897). 



22. Rubner, 'Gesetze des Energieverbrauchs,' p. 216, et seq. 



23. Kahn, 'Archiv fur (Anat. und) Phys.,' 1904, Sup., p. 1. 



24. Eisenschmid u. Schnitzler, 'Archiv Exp. Path, und Pharm.,' vol. 76, p. 202 (1914). 



25. Rubner, 'Gesetze des Energieverbrauchs,' p. 143. 



26. Rohde und Ogawa, 'Archiv Exp. Path, und Pharm.,' vol. 69, p. 200 (1912). 



27. Rubner, ' Gesetze des Energieverbrauchs,' p. 272. 



28. Krehl, ' Pathologische Physiologie,' 6te Auflage, p. 553 (1910). 



29. Rubner, Gesetze des Energieverbrauchs,' p. 156. 



