386 



Messrs. J. N. Langley and H. Sewall. [Nov. 27, 



and there branches out to the periphery, no cell outline at all can be 

 seen. A peripheral very finely granular almost homogeneous part. 



The necks of the glands are finely granular, with scattered small 

 dark granular patches. By treatment with 33 per cent, potash and 

 other re-agents, it can be seen that the dark granules are contained in 

 the chief- cells ; the outer finely granular or clear portion of the glands 

 being the border- cells. At the outer border, the outlines of the border- 

 cells can be well seen ; at the junctions of the cells, however, the 

 outlines disappear. No nuclei are visible. The small dark granular 

 patches in the necks of the glands are found to be also the chief-cells 

 which are here and there scattered amongst the border- cells. 



The pyloric glands in the fresh state are fairly transparent, finely 

 granular to homogeneous. The lumina-are usually distinct, and often 

 stretch up between the cells ; apart from this no cell outlines are visible. 

 No nuclei are to be seen. 



Heidenhain* described correctly the appearance of the fresh fundus 

 glands ; except that he mentions the nuclei of the border-cells as being 

 normally just visible. 



Ebstein.f I think, implies that the pyloric glands are normally not 

 coarsely granular. 



Yet Heidenhain, Ebstein, Grriitzner, and others, who advocate the 

 identity of the chief-cells with the pyloric gland cells, do not seem to 

 have noticed the difference existing between the two cells in the 

 fresh state. The difference is, however, most marked. 



The above description is of the chief-cells in the resting state. If 

 the glands are observed a few hours after a hungry animal has been 

 fed, the central granular mass in the body of the gland is found to 

 have very much diminished. A transverse section instead of showing 

 a thick mass of granules stretching here nearly, there quite to the peri- 

 phery, show a narrow rim or star of granules. 



During secretion then the granules of the chief-cells are used up. 



The stomach of the rabbit deserves especial consideration. It may 

 be divided into four portions, each in succession graduating into the 

 next. 



1. The Fundus or dilatation at the cardiac end of the stomach. This 

 is to the eye of an opaque white colour. The body of each gland 

 shows comparatively few border-cells, but consists mainly of a darkly 

 granular mass of chief- cells. 



2. The Greater Curvature. This is to the eye somewhat pink ; in 

 fresh specimens scarcely any dark granules are to be seen. In passing 

 from the fundus to the greater curvature, the number of dark granules 

 gradually diminishes, at first being confined more and more to the 



* Max Scliiiltze. " Arch. f. Mik. Aiiat." Bd. vi, p. 368, 1870. 

 f P. 515, 1870. 



