348 



Dr. A. J. Wall. On the [June 16, 



before a physiological effect is produced, except in those rare cases in 

 which an overwhelming quantity of poison is injected into a vein 

 directly. In man, after cobra poisoning, the blood is nearly always 

 found incoagulable, though in animals, especially dogs, the blood 

 generally coagulates as usual. That there is no great change in the 

 blood is evident from the fact that, when an animal has survived the 

 nerve symptoms produced by cobra poison, it is found to be quite well 

 and to suffer no further inconvenience from blood, poisoning or other 

 causes. 



Experiment VI. 



A large pariah dog had 5 mgrms. of dried cobra poison dissolved 

 in water injected into its hind leg. 

 12.12. p.m. Injection. 

 4 p.m. Vomited. 



7.30 p.m. Salivated. Looks depressed. 



10.15 p.m. Still depressed ; salivation slight ; respirations 14. 

 12.5 a.m. Still salivated ; very depressed. 



8 a.m. Very weak, hardly able to walk ; all the legs equally 

 affected. 



8.25 a.m. Respirations 12; pupils somewhat dilated, but contract to 

 light. Site of injection very red, hot, and swollen. 

 11.30 a.m. Respirations 15 ; frothy salivation. 

 12 p.m. Rectal temperature, 39° C. 



12.38 p.m. Pulse about 120, extremely irregular ; chewing move- 

 ment of jaw and lips ; salivation considerable. 



2.21 p.m. Better, can walk, salivation ceased ; ate sparingly. 



7.30 P.M- Recovering fast. Urinated — no albumen in the urine. 



8 a.m. Seems quite well. Purulent discharge from the site of the 

 . injection ; respirations 20, pulse 120. 



The dog was kept under observation but remained quite well. The 

 normal pulse rate was 90 and respirations 28. 



Here, though the most severe nerve symptoms were present, when 

 they passed off the animal was quite well, and suffered no further incon- 

 venience. The same also occurs in the human subject. Dr. Vincent 

 Richards relates a case of cobra poisoning, from his own observation, 

 in which a man lost completely all power over his legs, was unable to 

 speak, to move the lips, or to swallow, and where there was profuse 

 salivation, and yet after a few hours complete recovery ensued, the 

 man by the next day being well. The microscope also gives no evi- 

 dence of structural change in the blood. In cobra poisoning, also, 

 albumen in the urine is unknown. In animals that have suffered 

 most severely from nerve symptoms in which I have tested the urine, 

 albumen has not been present in a single case either fatal or non-fatal. 

 When, however, artificial respiration has been performed for some 



