368 Drs. Brunt on and Fayrdr on the Nature and Action [June 19, 



rabbit 7 milligrammes of extract : 5| minutes after the first injection the 

 animal became very restless. 



7'. Respiration rapid. The vessels of the ears were noticed to be 

 much injected. On continuing to observe them the injection disappeared 

 and then returned again. The alternate filling and emptying of the 

 vessels was much more perceptible than in the normal condition. The 

 rabbit sits quietly, but every now and then gives a start. 



22'. The condition of the ears has continued the same. The eyes are 

 becoming half shut and the eyeballs turned up. 



The animal now begins to tremble. The head is laid down on the 

 table and then raised again : this is succeeded by a nodding motion of 

 the head. The head is next laid down on the table. 



Eespirations 22 in 15 seconds. 



24'. The animal has sunk down on its face, and paws as if its fore legs 

 would no longer support it. The hind legs, however, still support the 

 posterior part of the body. Respirations 11 in 10 seconds. It seems to 

 be trying in vain to raise its head. 



26'. Respirations 8 in 10 seconds. Convulsions. The cornea is 

 sensitive. The rabbit is now lying on its side. Respirations 5 in 15 

 seconds. Pulse 12 in 18 seconds. 



31'. Cornea is nearly but not quite insensible. The eyeball is pro- 

 truding. 



About 31 h' respiration has stopped. The heart is still beating 

 vigorously. 



32'. Cornea insensible. The animal opened immediately. The heart 

 was beating vigorously ; 21 beats in 10 seconds. 



An attempt was made to insert electrodes into the spinal cord and 

 pass uninterrupted current through them. No effect followed ; but it is 

 not certain' that they were well in the cord. Irritation of the nerves 

 going to the hind legs by uninterrupted current had but a slight effect. 

 Direct irritation of the muscles caused them to contract. After the 

 irritation was discontinued, a fibrillary twitching was observed in one of 

 the extensions of the thigh. 



42'. Heart still feebly pulsating. Irritation of the brachial, sciatic, and 

 crural nerves has very little effect. 



45'. Heart still feebly pulsating. 



Experiment V. 



Two drops of cobra-poison were injected under the skin of the thigh 

 of a guineapig. 



One or two minutes after the injection the legs of the animal began to 

 twitch. It was then covered with a glass bell-jar. 



6' after injection. The legs are again twitching. This is a peculiar 

 motion of the hind legs, in which they seem to make an abortive attempt 

 to kick involuntarily. 



