1885.] produced by the Application of Cocaine to the Eye. 430 



Right eye, 5 instillations of cocaine, and pnpil 12 mm. 



Ten Days After. — Same experiment and same result. 



Two Months After. — Left eye, pupil 6'5 mm. x 4 - 5 mm. ; cocaine 

 4 per cent, three times, and no effect. 



Right eye, same experiment, and pupil became 11 mm. The injec- 

 tion of the vessels of the ears, &c, still continues. 



Brown Rabbit. — Pupils 7 5 mm. x 6 mm. under chloroform. Left 

 cervical sympathetic exposed, and 10 mm. cut out, followed by dilata- 

 tion of vessels of ear and slight contraction of pupil. Wound then 

 stitched up four days after. 



Left eye. Pupil : In bright light, 5.5 X 4 mm. In shade, 7 X 5*5 mm. 



Right eye. Pupil : In bright light, 5*5 x 4 mm. ; medium light, 

 7*5 X 6*5 mm. ; shade, 8*5 X 7'5 mm. 



2.30 p.m. Cocaine, 4 per cent., in both eyes. 



2.35 p.m. Pupils the same. Cocaine, 4 percent., repeated in each eye. 



2.40p.m. Left pupil in bright light, 5*5x4 mm.; in shade, 

 7x6 mm. Right pupil in bright light, 7x6 mm. ; in shade, 

 10x10 mm. 



Three other applications made, and same result. 



J ust as I had finished this paper I was enabled, through the kind- 

 ness of Mr. Nettleship, to see a case of lesion of the cervical sympa- 

 thetic on the right side, and am greatly indebted to him for allowing 

 me to use the following notes. It will be seen that numerous applica- 

 tions of cocaine had not the slightest effect on the pupil. 



B. P., 34. Married ; for four years in bad health ; seven months 

 slight difficulty in swallowing, and slight dyspnoea ; three months 

 noticed difference in feelings of warmth on the two sides of the face 

 — especially if excited ; five months noticed pupils unequal in size, 

 some fulness in middle of neck, but nothing definite to be felt. Little 

 more pulsation in right carotid than in left. 



y Right : -f : Jaeger i at 22 cm. 

 Left : |- : Jaeger i at 22 cm. 



Right eye. Palpebral fissure smaller than the left. Media clear and 

 normal. 



Pupil. — Regular, no iritic adhesions, acts to light and accommoda- 

 tion, smaller than left; when right pupil is 2 mm., left is 3*5 mm. 

 Looking at distant objects right pupil becomes 2J mm., when accom- 

 modating for 15 cm. it is 2 mm., and when shaded and accommodation 

 relaxed, 3 mm. 



Left eye. Pupil normal, acts to light and accommodation ; when well 

 shaded and accommodation relaxed it is 6 mm. On taking these notes, 

 the one-sided flushing of the face was noticed. Six instillations of 

 cocaine, 2 per cent., in the right eye, gave rise to no alteration in the 

 size of the pupil. 



