288 



Dr. C. R. A. Wright on the Opium Alkaloids. [Apr. 11, 



Eeagent &c. 



Codeia. 



Bicodeia. 



Tricodeia. 



Tetracodeia. 



Alcohol 



Ether 



Character of base 



Character of hy- 

 drochlorate. 



Ferric chloride 



Citric acid 



Potassium dichro- 

 mate and sulphu- 

 ric acid. 



Sodium carbonate 

 and solution of 

 hydrochlorate. 



Caustic potash and 

 solution of hy- 

 drochlorate. 



Action of hydro- 

 chloric acid, not 

 pushed to ex- 1 

 treme. 



Action of hydrio- 

 dic acid, in con- 

 junction with 

 phosphorus, not 

 pushed to ex- 

 treme. 



Action of sulphu- 

 ric acid, not 

 pushed to ex- 

 treme. 



Formula inferred 

 from above pro- 

 perties and reac-| 

 tions. 



Physiological ac- 

 tion of Ol grin.' 

 of anhydrous hy-| 

 drochlorate sub- J 

 cutaneously in- 

 jected into adult 

 cats. 



Soluble Soluble j 



Soluble _ I Soluble j 



Crystalline, stable! Amorphous, stable| 

 in the air. j in the air. 



Crystallizes with Crystallizes with 

 2H o for C 1S .| 3H 9 for C J8 ; 

 not lost at 100°. 1 lost at 100°, and; 



partially at lower' 

 temperatures 

 Ml Nil when pure 



Light orange : Light orange ., 



Nil Nil 



No immediate 

 precipitate, crys-| 

 tals on standing. 



Oily precipitate, if 

 concentrated, be- 

 coming crystal- 

 line on standing. 

 Not markedly 

 soluble in excess. 



Product contains 

 CI for C 3 , 3 ; fur- 

 ther action con- 

 tains Cl 2 for C 3( J 



Polymerizes with] 

 elimination of 

 CH 3 for C 1S . ! 

 forming bases 

 derived from; 

 (C 17 H 2l N0 3 ) 8 , I 

 H being added 

 on for C 17 in 

 product. 

 Polymerizes, form- 

 ing successively ; 

 di-, fori-, and te-; 

 tracodeia. 

 C 36 H, 2 N 2 G . | 



Extreme hyper- 

 sensitiveness and 

 cerebral conges- 

 tion, dilatation; 

 of pupils ; no 

 diarrhoea ; no 

 vomitiig in any 

 instance. 



Soluble 



Soluble 



Amorphous. Very 



slowly oxidizes 



while moist. 

 Non-crystalline, ! 



extremely deli-; 



que scent. 



No colour at first, 

 reddish purple 

 on standing. 



Blood-red 



Evanescent red 



Instantaneous j Same as dicodeia 



amorphous pre- 

 cipitate but little 



soluble in excess.; 

 Oily precipitate, if Same as dicodeia 



concentrated,not: 



becoming crys-j 



talline ; moredi-! 



lute solutions' 



give a white 



amorphous pre- 1 



cipitate soluble 



in large excess. 

 Product contains 



CI for CL>. 



Soluble. 



Insoluble. 



Amorphous. Very 

 slowly oxidizes 

 while moist, 



Non-crystalline, 

 deliquescent. 



Eeddish-purple 

 colour immedi 

 ately. 



Blood-red. 



Evanescent red. 



Same as dicodeia. 



Same as diccde 



H 2 O removed for 

 C 1S ; no basic CI 

 contained in 

 product. 



CH 3 for 

 forming 



Polymerizes with 

 elimination of 



oJ 



bases; 



derived" from 1 

 (C 17 H 20 NO 3 ) s . ! 

 H being added 

 on for C 17 in 

 product. 

 Polymerizes, form- 

 ing tetracodeia. 



C 72 H 84 N 4 12 .... C 108 H 126 N e 18 . 



No hypersensitive- Hypersensitiveness 



ness nor cerebral scarcely marked, 



congestion; di- vomiting in some 



latation of pu- instances, in 



pils ; vomiting in others salivation 



every instance. | and defalcation. 



With a dog pro-j 

 fuse diarrhoea; 

 without vomit- 

 ing- 



Nil. 



CH 3 eliminated] 

 for C ls ; product! 

 derived from 

 (C 1T H 19 N0 3 ), s , 

 no H being 

 added on, but 

 simply I substi-j 

 tuted for OH. | 



Nil. Further 

 action probably 

 dehydrates and 

 oxidizes. 



No hypersensi- 

 tiveness ; vomit- 

 in g, salivation, 

 in 



cr diarrhoea 

 every case : great i 

 depression. 

 With a dog pro-, 

 fuse salivation 

 and depression. 



